ArticleNucleic acids research1991
E1A dependent up-regulation of c-jun/AP-1 activity.
Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Sprouty is a cytoplasmic target of adenoviral E1A oncoproteins to regulate the receptor tyrosine kinase signalling pathway.Virology journal · 2011Article
- Regulation of MAPKs by growth factors and receptor tyrosine kinases.Biochimica et biophysica acta · 2007Review
- JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells.Molecular and cellular biology · 2002Article
- p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells.Genes & development · 1998Article
- The CR1 and CR3 domains of the adenovirus type 5 E1A proteins can independently mediate activation of ATF-2.Journal of virology · 1996Article
- The human papillomavirus type 16 E7 protein complements adenovirus type 5 E1A amino-terminus-dependent transactivation of adenovirus type 5 early genes and increases ATF and Oct-1 DNA binding activity.Journal of virology · 1996Article
- Transcriptional transactivation of parvovirus B19 promoters in nonpermissive human cells by adenovirus type 2.Journal of virology · 1995Article
- CBP-induced stimulation of c-Fos activity is abrogated by E1A.The EMBO journal · 1995Article
- Phosphorylation of the adenovirus E1A-associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells.The EMBO journal · 1995Article
- A novel pathway for retinoic acid-induced differentiation of F9 cells that is distinct from receptor-mediated trans-activation.In vitro cellular & developmental biology. Animal · 1994Article
- The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator.Molecular and cellular biology · 1994Article
- Assignment of rat Jun family genes to chromosome 19 (Junb), chromosome 5q31-33 (Jun), and chromosome 16 (Jund).Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Different TRE-related elements are distinguished by sets of DNA-binding proteins with overlapping sequence specificity.Nucleic acids research · 1993Article
- Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.The EMBO journal · 1993Article
- Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells.The EMBO journal · 1992Article
- The adenovirus E1A transforming protein activates the proliferating cell nuclear antigen promoter via an activating transcription factor site.Journal of virology · 1991Article
- Activation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICPO.Nucleic acids research · 1991Article
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4 authors.
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Abstract
E1A, the early region 1A transcription unit of human adenovirus, exhibits multiple functions that regulate the expression of some cellular genes and promote cell growth and division. We found that E1A stimulated c-jun gene expression at least fifty-fold in rat 3Y1 cells in a serum-independent manner, concomitantly with E1A down-regulation of jun B expression. The E1A-dependent induction of c-jun transcription resulted in increase amount of cJun/AP1. This induction was mediated by the enhancement of the binding activity of the transcription factor cJun/AP1 to an AP1 binding site in the c-jun promoter. Additionally, this induction can be repressed by introducing junB into the cells. Taken collectively, these results suggest that the differential expression of two closely related proteins greatly expands their cellular regulation. Induction of c-jun expression by E1A as well as c-jun autoregulation may amplify the action of E1A during adenovirus infection. Therefore, some of the biological effects of E1A may include mediating the constitutive activation of c-jun, which is important in transcriptional regulation and oncogenic transformation.
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