ReviewTrends in immunology2008
The convergent roles of tapasin and HLA-DM in antigen presentation.
Review in Trends in immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Partnering for the major histocompatibility complex class II and antigenic determinant requires flexibility and chaperons.Current opinion in immunology · 2021Review
- How a Proposed Hypothesis during My PhD Training Shaped My Career.Critical reviews in immunology · 2020Article
- What to do with HLA-DO/H-2O two decades later?Immunogenetics · 2019Review
- The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling.Frontiers in immunology · 2018Review
- Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation.Frontiers in immunology · 2017Review
- A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cells.F1000Research · 2016Review
- The MHC class II cofactor HLA-DM interacts with Ig in B cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- For many but not for all: how the conformational flexibility of the peptide/MHCII complex shapes epitope selection.Immunologic research · 2013Review
- Calreticulin in the immune system: ins and outs.Trends in immunology · 2013Review
- Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection.Cell · 2012Article
- Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner.BMC genomics · 2012Article
- The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway.Current opinion in immunology · 2012Review
- A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes.Nature medicine · 2010Article
- Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection.Immunologic research · 2010Review
- Overview of the immune response.The Journal of allergy and clinical immunology · 2010Review
- Burkitt lymphoma: pathogenesis and immune evasion.Journal of oncology · 2010Article
- Understanding the focused CD4 T cell response to antigen and pathogenic organisms.Immunologic research · 2009Review
- HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1.Molecular immunology · 2009Article
- MHC class I antigen presentation: learning from viral evasion strategies.Nature reviews. Immunology · 2009Review
- Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.Immunity · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Cytotoxic and helper T cells respond to peptides derived from endogenous and exogenous sources that bind to major histocompatibility complex (MHC) class I and class II molecules and are presented on antigen-presenting cells. MHC class I and class II structures and maturation pathways have evolved to optimize antigen presentation to their respective T cells. The accessory proteins tapasin and HLA-DM (DM) crucially influence the selection of peptides that bind to the MHC molecules. We discuss here the dynamic interactions of tapasin and DM with their corresponding MHC molecules that indicate striking parallels. Utilization of a common mode of peptide selection by two different, but related, biological systems argue for its mechanistic validity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.