Evidence map›Paper›PMID 18261920›Full record

ReviewSeminars in immunology2008

Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function.

Christopher D C Allen, Jason G Cyster

Abstract readReview
In one paragraph

Review in Seminars in immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 236 papers.

0numbers the graph read from it
0cells of the map it votes in
236citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

236 citing papers in PubMed.

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  10. Extrafollicular and other non-germinal center B cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
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176 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christopher D C AllenHoward Hughes Medical Institute and Department of Microbiology and Immunology, 513 Parnassus Avenue, Box 0414, University of California, San Francisco, CA 94143-0414, USA. Chris.Allen@ucsf.edu
Jason G Cyster

Funding

Chemokines and Lymphoid Tissue Organization and FunctionR01AI045073 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1999 to 2023
$7.6M
Beta Lymphocyte Migration and HomeostasisR37AI040098 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 2002 to 2011
$3.2M
Chemokines and Lymphoid Tissue Organization and FunctionR37AI045073 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason G Cyster · 2024 to 2026
$1.7M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI045073NIAID NIH HHS R37 AI040098NIAID NIH HHS R37 AI045073
6 · The paper itself

Abstract

Follicular dendritic cells (FDCs) were identified decades ago by their ability to retain immune complexes and more recent findings indicate that they are a source of B cell attractants and trophic factors. New imaging studies have shown that B cells closely associate with their dendritic processes during migration. Here we will review the properties of these specialized follicular stromal cells and provide an update on the requirements for their maturation into phenotypically distinct cells within germinal center light and dark zones. We will then discuss current understanding of how they help support the B cell immune response.

Indexed as

Antigen PresentationImmunologic MemoryParacrine CommunicationAnimalsAntibody FormationAntigen-Antibody ComplexAntigens, DifferentiationBiological Transport, ActiveB-LymphocytesDendritic Cells, FollicularGerminal CenterHumansMiceRatsReceptors, IgEReceptors, IgGAntigen-Antibody ComplexAntigens, DifferentiationReceptors, IgEReceptors, IgG

Identifiers

PMID18261920
PMCPMC2366796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.