SynthesisAddiction (Abingdon, England)2008
Meta-analysis of depression and substance use and impairment among intravenous drug users (IDUs).
Synthesis in Addiction (Abingdon, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Pooled it
- Meta-analysis of depression and substance use among individuals with alcohol use disorders.Journal of substance abuse treatment · 2009Pooled it
- Meta-analysis of depression and substance use and impairment among cocaine users.Drug and alcohol dependence · 2008Pooled it
- Substance use and mental health before versus during COVID-19 pandemic among persons who inject drugs with HCV infection history-the HERO study.Harm reduction journal · 2026Trial
- Trial
- Relationship between opioid cross-tolerance during buprenorphine stabilization and return to opioid use during buprenorphine dose tapering.Psychopharmacology · 2024Trial
- Trial
- The moderating effects of group cognitive-behavioral therapy for depression among substance users.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2012Trial
- Unemployment & opioid use disorder - socio-medical assessment results by the Medical Service of the German Federal Employment Agency.Substance abuse treatment, prevention, and policy · 2026Article
- Exploring the Role of Racial Microaggressions in the Association Between Depression Symptoms and Drug Use and Related Harm Among Women of Color Experiencing Intimate Partner Violence.Journal of dual diagnosis · 2025Article
- Testing the Relationships Between Multiple Domains of Substance Use‑Related Stigma and Depression Among a Sample of Young (18-30‑Year‑Old) People Who Inject Drugs in the Greater Chicago Area.International journal of mental health and addiction · 2025Article
- Transgender and Gender-Diverse Minority Stress and Substance Use Frequency and Problems: Systematic Review and Meta-Analysis.Transgender health · 2025Review
- Identification of Behavioral, Clinical, and Psychological Antecedents of Acute Stimulant Poisoning: Development and Implementation of a Mixed Methods Psychological Autopsy Study.JMIR formative research · 2025Article
- Psychiatric comorbidities and concurrent substance use among people who inject drugs: a single-centre hospital-based study.Scientific reports · 2023Article
- Reduction in Depressive Symptoms in People who Inject Drugs who Are Cured of Hepatitis C Virus Infection: The HERO Study.Open forum infectious diseases · 2023Article
- Temporal association of pre-pandemic perceived social support with psychological resilience and mental well-being during the COVID-19 pandemic among people with a history of injection drug use.Drug and alcohol dependence · 2023Article
- Impact of Hepatitis C Virus Cure on Depressive Symptoms in the Human Immunodeficiency Virus-Hepatitis C Virus Coinfected Population in Canada.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Gender, homelessness, hospitalization and methamphetamine use fuel depression among people who inject drugs: implications for innovative prevention and care strategies.Frontiers in psychiatry · 2023Article
- Article
- Coping strategies and their association with diabetes specific distress, depression and diabetes self-care among people living with diabetes in Zambia.BMC endocrine disorders · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
aimsTo evaluate, among intravenous drug users (IDUs), the hypothesized positive association of depression with substance-related behaviors including concurrent drug use and impairment, future drug use and impairment, alcohol use and impairment, needle sharing and substance use treatment participation, and to identify moderators of these associations.
designMeta-analysis of reports on IDUs published in English in peer-reviewed journals since 1986 that contained data on depression and substance use outcome(s) with no restrictions on range of depression scores to select the sample.
settingFifty-five reports containing 55 samples met criteria, including 42 (76%) samples from clinical venues and 13 (24%) that were community-based.
participantsMean age was 34.3 (standard deviation = 4.5) years, comprising approximately 68% men and 43% white, non-Hispanic subjects. MEASUREMENTS: Depression was assessed with the Beck Depression Inventory, Center for Epidemiological Studies Depression Scale (CES-D) and other validated scales or diagnostic interviews. The Addiction Severity Index was the most frequently used measure of substance-related outcomes.
findingsA priori hypotheses pertaining to depression and the substance-related variables were supported, with the exception of the predicted association of depression and future drug use and impairment. Effect sizes were small. Moderating effects of gender were identified, including greater associations of depression with substance use treatment participation and needle sharing among women and a greater association of depression with future drug use and impairment among men. Effect sizes of moderators were large.
conclusionsDepression is associated with several substance-related behaviors, and select associations are stronger according to gender. Prospective associations of depression with future drug use and impairment are not immediately evident, but could be examined in subsequent research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.