ArticleThe Journal of comparative neurology2008
Identification of molecular markers of bipolar cells in the murine retina.
Article in The Journal of comparative neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 116 citations in OpenAlex.
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- Light drives the developmental progression of outer retinal function.The Journal of general physiology · 2023Article
- PLAE Web App Enables Powerful Searching and Multiple Visualizations Across One Million Unified Single-Cell Ocular Transcriptomes.Translational vision science & technology · 2023Article
- Disease-causing mutations in genes encoding transcription factors critical for photoreceptor development.Frontiers in molecular neuroscience · 2023Review
- Targeted Expression of Retinoschisin by Retinal Bipolar Cells in XLRS Promotes Resolution of Retinoschisis Cysts Sans RS1 From Photoreceptors.Investigative ophthalmology & visual science · 2022Article
- Involvement of transient receptor potential channels in ocular diseases: a narrative review.Annals of translational medicine · 2022Article
- Essential Functions of MLL1 and MLL2 in Retinal Development and Cone Cell Maintenance.Frontiers in cell and developmental biology · 2022Article
- A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq.Developmental biology · 2021Review
- Primary Cilia in Amacrine Cells in Retinal Development.Investigative ophthalmology & visual science · 2021Article
- Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells.Gene therapy · 2021Article
- Starvation to Glucose Reprograms Development of Neurovascular Unit in Embryonic Retinal Cells.Frontiers in cell and developmental biology · 2021Article
- TRPM Channels in Human Diseases.Cells · 2020Review
- Expression and Localization of Kcne2 in the Vertebrate Retina.Investigative ophthalmology & visual science · 2020Article
- Rod bipolar cells dysfunction occurs before ganglion cells loss in excitotoxin-damaged mouse retina.Cell death & disease · 2019Article
- Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina.Cell reports · 2019Article
- Nucleome Dynamics during Retinal Development.Neuron · 2019Article
- Molecular signatures of retinal ganglion cells revealed through single cell profiling.Scientific reports · 2019Article
- Functional characterization of retinal ganglion cells using tailored nonlinear modeling.Scientific reports · 2019Article
- Retinal Phenotype in the rd9 Mutant Mouse, a Model of X-Linked RP.Frontiers in neuroscience · 2019Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Retinal bipolar neurons serve as relay interneurons that connect rod and cone photoreceptor cells to amacrine and ganglion cells. They exhibit diverse morphologies essential for correct routing of photoreceptor cell signals to specific postsynaptic amacrine and ganglion cells. The development and physiology of these interneurons have not been completely defined molecularly. Despite previous identification of genes expressed in several bipolar cell subtypes, molecules that mark each bipolar cell type still await discovery. In this report, novel genetic markers of murine bipolar cells were found. Candidates were initially generated by using microarray analysis of single bipolar cells and mining of retinal serial analysis of gene expression (SAGE) data. These candidates were subsequently tested for expression in bipolar cells by RNA in situ hybridization. Ten new molecular markers were identified, five of which are highly enriched in their expression in bipolar cells within the adult retina. Double-labeling experiments using probes for previously characterized subsets of bipolar cells were performed to identify the subtypes of bipolar cells that express the novel markers. Additionally, the expression of bipolar cell genes was analyzed in Bhlhb4 knockout retinas, in which rod bipolar cells degenerate postnatally, to delineate further the identity of bipolar cells in which novel markers are found. From the analysis of Bhlhb4 mutant retinas, cone bipolar cell gene expression appears to be relatively unaffected by the degeneration of rod bipolar cells. Identification of molecular markers for the various subtypes of bipolar cells will lead to greater insights into the development and function of these diverse interneurons.
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