ArticleJournal of genetic counseling2008
Psychological factors associated with emotional responses to receiving genetic risk information.
Article in Journal of genetic counseling, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Viewing direct-to-consumer genetic test results for depression risk is psychologically well tolerated: Evidence from a longitudinal equivalence study.HGG advances · 2026Article
- Article
- Effects of diet education on empowerment for individuals who have an increased risk of developing breast or colon cancer: A pilot study.Journal of genetic counseling · 2022Article
- How does genetic testing influence anxiety, depression, and quality of life? A hereditary breast and ovarian cancer syndrome suspects trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- microRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens.The Journal of biological chemistry · 2020Article
- microRNA and mRNA profiles in the amygdala are associated with stress-induced depression and resilience in juvenile mice.Psychopharmacology · 2019Article
- microRNA and mRNA profiles in nucleus accumbens underlying depression versus resilience in response to chronic stress.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
- Coping Profiles Differentiate Psychological Adjustment in Chinese Women Newly Diagnosed With Breast Cancer.Integrative cancer therapies · 2017Article
- GABAergic neurons in nucleus accumbens are correlated to resilience and vulnerability to chronic stress for major depression.Oncotarget · 2017Article
- Emotional impact on the results of BRCA1 and BRCA2 genetic test: an observational retrospective study.Hereditary cancer in clinical practice · 2017Article
- Hopes and Expectations Regarding Genetic Testing for Schizophrenia Among Young Adults at Clinical High-Risk for Psychosis.Journal of psychiatric practice · 2016Article
- Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress.Translational psychiatry · 2016Article
- Incoordination among Subcellular Compartments Is Associated with Depression-Like Behavior Induced by Chronic Mild Stress.The international journal of neuropsychopharmacology · 2016Article
- Glucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala.PloS one · 2016Article
- Molecular Mechanism for Stress-Induced Depression Assessed by Sequencing miRNA and mRNA in Medial Prefrontal Cortex.PloS one · 2016Article
- Do Attachment Style and Emotion Regulation Strategies Indicate Distress in Predictive Testing?Journal of genetic counseling · 2015Article
- Short-term psychological impact of the BRCA1/2 test result in women with breast cancer according to their perceived probability of genetic predisposition to cancer.British journal of cancer · 2013Article
- Genetic counseling as a tool for type 2 diabetes prevention: a genetic counseling framework for common polygenetic disorders.Journal of genetic counseling · 2012Article
- Factors associated with intrusive cancer-related worries in women undergoing cancer genetic risk assessment.Familial cancer · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study identified levels of distress, and predictors of levels of distress, in women undergoing assessment for genetic risk of breast/ovarian cancer based on their family history. It comprised a cohort study following 154 women who completed questionnaires at entry into a cancer genetic assessment programme and following risk provision. Independent significant associates of anxiety following risk provision were age, neuroticism, feeling hopeless about developing cancer, a perceived lack of control over developing cancer, lack of a social confidant, and a coping response involving acceptance/resignation. Depression was associated with age, neuroticism, feeling hopeless about developing cancer, lack of social confidant, and a coping response involving acceptance/resignation. To avoid high levels of psychological morbidity in future cohorts undergoing cancer genetic risk assessment, information should be given that emphasises that some degree of control over health outcomes through behaviour change or increased surveillance is possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.