ArticleWorld journal of surgery2008
Risk factors and clinical outcome for anastomotic leakage after total mesorectal excision for rectal cancer.
Article in World journal of surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 7 of them syntheses that pooled it.
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Who cites it
75 citing papers in PubMed, 7 syntheses or guidelines pooled it, 181 citations in OpenAlex.
- Preoperative risk factors associated with anastomotic leakage after colectomy for colorectal cancer: a systematic review and meta-analysis.Revista do Colegio Brasileiro de Cirurgioes · 2022Pooled it
- Meta-analysis of the impact of postoperative infective complications on oncological outcomes in colorectal cancer surgery.BJS open · 2020Pooled it
- Pooled it
- Anastomotic leak and cancer-specific outcomes after curative rectal cancer surgery: a systematic review and meta-analysis.Techniques in coloproctology · 2020Pooled it
- Prediction of anastomotic leak in colorectal cancer surgery based on a new prognostic index PROCOLE (prognostic colorectal leakage) developed from the meta-analysis of observational studies of risk factors.International journal of colorectal disease · 2016Pooled it
- A meta-analysis of the use of a transanal drainage tube to prevent anastomotic leakage after anterior resection by double-stapling technique for rectal cancer.Surgical endoscopy · 2016Pooled it
- Incidence and mortality of anastomotic dehiscence requiring reoperation after rectal carcinoma resection.International surgeryPooled it
- Neoadjuvant treatment of mid-to-lower rectal cancer with oxaliplatin plus 5-fluorouracil and leucovorin in combination with radiotherapy: a Korean single center phase II study.International journal of clinical oncology · 2013Trial
- Use of a transanal drainage tube for prevention of anastomotic leakage and bleeding after anterior resection for rectal cancer.World journal of surgery · 2013Trial
- Risk factor analysis of postoperative complications after robotic rectal cancer surgery.World journal of surgery · 2011Trial
- Protection of intestinal anastomosis with biological glues: an experimental randomized controlled trial.Techniques in coloproctology · 2011Trial
- ETVARD (endoscopic transanal vacuum-assisted rectal drainage) leads to complete but delayed closure of extraperitoneal rectal anastomotic leakage cavities following neoadjuvant radiochemotherapy.International journal of colorectal disease · 2009Trial
- Articulation analysis of robotic staplers in rectal surgery.Surgery today · 2026Article
- Anastomotic leakage in colorectal cancer surgery in Syria: risk factors and improvements following guideline implementation - a retrospective cohort study.Annals of medicine and surgery (2012) · 2026Article
- Does robotic circumferential oversewing reduce anastomotic leakage in stapled anastomosis for rectal cancer surgery?Techniques in coloproctology · 2025Article
- A novel technique for low-rectal cancer: Pushing the anus in laparoscopic radical resection.Medicine · 2025Observational
- Pull-through endoscopic vacuum-assisted closure therapy for complicated leaks of the gastrointestinal tract: Novel technique.Endoscopy international open · 2025Article
- Effective initial management of anastomotic leak in the maintenance of functional colorectal or coloanal anastomosis.Surgery today · 2023Article
- Impact of anastomotic leakage on long-term prognosis after colorectal cancer surgery.World journal of gastrointestinal surgery · 2023Review
- Endoscopic vacuum-assisted closure therapy for leakage of the lower gastrointestinal tract: multicenter experiences.Endoscopy international open · 2023Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnastomosis leakage is a major complication of rectal surgery. The aim of this study was to identify risk factors for anastomotic leakage after low anterior resection (LAR) in rectal cancer patients and study its impact on long-term prognosis and disease-free survival and overall survival in rectal cancer patients.
methodsConsecutive patients who underwent rectal resection with primary anastomosis below the pelvic peritoneal reflexion for rectal cancer between October 1996 to February 2006 were included.
resultsAnastomosis leakage after LAR occurred in 51 patients (4.0%). The median time to leakage was 4 days (range = 2-30 days). In univariate analysis, gender, level of anastomosis less than 4 cm, preoperative concomitant chemoradiation (CCRT), and length of operation greater than 120 min were significantly associated with anastomosis leakage. In a multivariate analysis, gender (p = 0.041; relative risk = 2.007; 95% CI = 1.030-3.912) and preoperative CCRT (p = 0.003; relative risk = 2.861; 95% CI = 1.417-5.778) were identified as independent prognostic factors. The overall survival of the nonleakage group and the leakage group was 80.2% and 64.9%, respectively (p = 0.170). The 5-year disease-free survival rates were not significantly different between the nonleakage and leakage groups (78.1% vs. 65.9%, p = 0.166).
conclusionsThe incidence of anastomotic leakage after low anterior resection is relatively low. Male gender and preoperative CCRT were associated with increased risk for anastomotic leakage after rectal cancer surgery. No effect of anastomosis leakage on local recurrence was found in this series.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.