ArticleThe Journal of clinical investigation2008
A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation.
Article in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus.Epigenetics & chromatin · 2020Article
- Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice.Epigenetics & chromatin · 2018Article
- Homeostatic Response of MouseMolecular and cellular biology · 2018Article
- The PPAR-gamma-binding sequence Pal3 is necessary for basal but dispensable for high-fat diet regulated human renin expression in the kidney.Pflugers Archiv : European journal of physiology · 2017Article
- Article
- A polymorphism of the renin gene rs6682082 is associated with essential hypertension risk and blood pressure levels in Korean women.Yonsei medical journal · 2015Article
- Classical Renin-Angiotensin system in kidney physiology.Comprehensive Physiology · 2014Review
- The H19 imprinting control region mediates preimplantation imprinted methylation of nearby sequences in yeast artificial chromosome transgenic mice.Molecular and cellular biology · 2013Article
- Control of renin [corrected] gene expression.Pflugers Archiv : European journal of physiology · 2013Review
- Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- cAMP target sequences enhCRE and CNRE sense low-salt intake to increase human renin gene expression in vivo.Pflugers Archiv : European journal of physiology · 2011Article
- The renin phenotype: roles and regulation in the kidney.Current opinion in nephrology and hypertension · 2010Review
- Long human CHGA flanking chromosome 14 sequence required for optimal BAC transgenic "rescue" of disease phenotypes in the mouse Chga knockout.Physiological genomics · 2010Article
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7 authors.
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Abstract
Renin, a major regulatory component of the renin-angiotensin system, plays a pivotal role in regulating blood pressure and electrolyte homeostasis and is predominantly expressed in the kidney. Several cAMP-responsive elements have been identified within renin gene promoters. Here, we study how 2 such elements, renin proximal promoter element-2 (RP-2) and overlapping cAMP and negative regulatory elements (CNRE), affect the transcriptional regulation of renin. We generated Tg mice (TgM) bearing BACs containing either WT or mutant RP-2 or CNRE, integrated at single chromosomal loci. Analysis of the TgM revealed that RP-2 was essential to basal promoter activity in the kidney, while renin mRNA levels did not significantly change in any tissues tested in the CNRE mutant TgM. To evaluate the physiological significance of these mutations, we used the BAC Tg to rescue hypotensive Renin-null mutant mice. As predicted, no renin expression was observed in the kidneys of RP-2 mutant/Renin-null compound mice, whereas renin expression in CNRE mutant compound mice was indistinguishable from that in control mice. Consistent with this, RP-2 mutant animals were hypotensive, while CNRE mutants had normal blood pressure. Thus, transcriptional regulation of renin expression via RP-2 but not CNRE is critical for blood pressure regulation by this gene.
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