ArticleProceedings of the National Academy of Sciences of the United States of America2008
WIP is essential for lytic granule polarization and NK cell cytotoxicity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- DIAPH1-Deficiency is Associated with Major T, NK and ILC Defects in Humans.Journal of clinical immunology · 2024Article
- Exploration of the immune cell infiltration-related gene signature in the prognosis of melanoma.Aging · 2021Article
- The Role of the Cytoskeleton in Regulating the Natural Killer Cell Immune Response in Health and Disease: From Signaling Dynamics to Function.Frontiers in cell and developmental biology · 2021Review
- Article
- Unleashing Natural Killer Cells in the Tumor Microenvironment-The Next Generation of Immunotherapy?Frontiers in immunology · 2020Review
- Signals Controlling Lytic Granule Polarization at the Cytotoxic Immune Synapse.Frontiers in immunology · 2018Review
- The Phenotype and Treatment of WIP Deficiency: Literature Synopsis and Review of a Patient With Pre-transplant Serial Donor Lymphocyte Infusions to Eliminate CMV.Frontiers in immunology · 2018Review
- Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome Patients.Frontiers in immunology · 2017Article
- Human Immunodeficiencies Related to Defective APC/T Cell Interaction.Frontiers in immunology · 2015Review
- Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing.Molecular and cellular biology · 2014Article
- Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Ly49C-dependent control of MCMV Infection by NK cells is cis-regulated by MHC Class I molecules.PLoS pathogens · 2014Article
- Cell biological steps and checkpoints in accessing NK cell cytotoxicity.Immunology and cell biology · 2014Review
- Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity.Frontiers in immunology · 2014Review
- Activation of Lymphocyte Cytolytic Machinery: Where are We?Frontiers in immunology · 2013Review
- In and out of the bull's eye: protein kinase Cs in the immunological synapse.Trends in immunology · 2013Review
- The immunomodulating roles of glycoproteins in epithelial ovarian cancer.Frontiers in bioscience (Elite edition) · 2012Review
- Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity.Frontiers in immunology · 2012Article
- WIP remodeling actin behind the scenes: how WIP reshapes immune and other functions.International journal of molecular sciences · 2012Review
- Human NK cell lytic granules and regulation of their exocytosis.Frontiers in immunology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Natural killer (NK) cells play important roles in host immunity by killing virus-infected and tumor cells. Killing of the target cell is achieved by formation of an immune synapse and localized secretion of lytic granules containing perforin and granzymes. Here, we demonstrate that Wiskott-Aldrich syndrome protein (WASp)-interacting protein (WIP), important in generation of a large complex of proteins involved in actin cytoskeleton rearrangements, is indispensable for NK cell cytotoxicity. WIP knockdown completely inhibited cytotoxicity, whereas overexpression of WIP enhanced NK cell cytolytic ability. WIP was found to colocalize with lytic granules. WIP segregated to the lysosomal fraction, where granzyme B activity was also found, and the interaction between WIP and granules was independent of WASp. Importantly, WIP knockdown inhibited polarization of lytic granules to the immune synapse, but not conjugate formation. These results indicate that WIP is involved in lytic granule transport and is essential for regulation of NK cell cytotoxic function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.