ArticleThe Journal of physiology2008
Interplay between neuromodulator-induced switching of short-term plasticity at sensorimotor synapses in the neonatal rat spinal cord.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Cell Type-Dependent Short-Term Plasticity and Dopaminergic Modulation of Sensory Synapses onto Mouse Superficial Dorsal Horn Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Decoding the structural and functional diversity of GABAFrontiers in pharmacology · 2025Review
- Biological data questions the support of the self inhibition required for pattern generation in the half center model.PloS one · 2020Article
- Stability of working memory in continuous attractor networks under the control of short-term plasticity.PLoS computational biology · 2019Article
- The Mechanistic Basis for Successful Spinal Cord Stimulation to Generate Steady Motor Outputs.Frontiers in cellular neuroscience · 2019Article
- Gliotransmission and adenosinergic modulation: insights from mammalian spinal motor networks.Journal of neurophysiology · 2017Review
- The transformation of synaptic to system plasticity in motor output from the sacral cord of the adult mouse.Journal of neurophysiology · 2015Article
- Neuromodulation of neurons and synapses.Current opinion in neurobiology · 2014Review
- Monoaminergic control of spinal locomotor networks in SOD1G93A newborn mice.Frontiers in neural circuits · 2014Article
- Neuromodulatory changes in short-term synaptic dynamics may be mediated by two distinct mechanisms of presynaptic calcium entry.Journal of computational neuroscience · 2012Article
- Neuromodulator-evoked synaptic metaplasticity within a central pattern generator network.Journal of neurophysiology · 2012Article
- Peptide neuromodulation of synaptic dynamics in an oscillatory network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Cholinergic partition cells and lamina x neurons induce a muscarinic-dependent short-term potentiation of commissural glutamatergic inputs in lumbar motoneurons.Frontiers in neural circuits · 2011Article
- Noradrenergic modulation of intrinsic and synaptic properties of lumbar motoneurons in the neonatal rat spinal cord.Frontiers in neural circuits · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we investigated the modulation of short-term depression (STD) at synapses between sensory afferents and rat motoneurons by serotonin, dopamine and noradrenaline. STD was elicited with trains of 15 stimuli at 1, 5 and 10 Hz and investigated using whole-cell voltage-clamp recordings from identified motoneurons in the neonatal rat spinal cord in vitro. STD was differentially modulated by the amines. Dopamine was effective at all stimulation frequencies, whereas serotonin affected STD only during 5 and 10 Hz stimulus trains and noradrenaline during 1 and 5 Hz trains. Dopamine and serotonin homogenized the degree of depression observed with the different stimulation modalities, in contrast to noradrenaline, which amplified the rate differences. The different modulatory profiles observed with the amines were partly due to GABAergic interneuron activity. In the presence of GABA(A) and GABA(B) receptor antagonists, the rate and/or kinetics of STD did not vary with the stimulation frequency in contrast to the control condition, and noradrenaline failed to alter either synaptic amplitude or STD, suggesting indirect actions. Dopamine and serotonin strongly decreased STD and converted depression to facilitation at 5 and 10 Hz during the blockade of the GABAergic receptors in 50% of the neurons tested. Altogether, these results show that STD expressed at sensorimotor synapses in the neonatal rat not only is a function of the frequency of afferent firing but also closely depends on the neuromodulatory state of these connections, with a major contribution from GABAergic transmission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.