ArticleThe Journal of physiology2008
4-Aminopyridine-sensitive outward currents in preBötzinger complex neurons influence respiratory rhythm generation in neonatal mice.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 28 citations in OpenAlex.
- μ-Opioid receptor signalling enhances Kir3 currents in glutamatergic preBötzinger complex neurons in mice.The Journal of physiology · 2026Article
- Modeling insights into potential mechanisms of opioid-induced respiratory depression within medullary and pontine networks.Journal of neurophysiology · 2026Article
- Review
- Review
- A novel mechanism for ramping bursts based on slow negative feedback in model respiratory neurons.Chaos (Woodbury, N.Y.) · 2024Article
- Inspiratory and sigh breathing rhythms depend on distinct cellular signalling mechanisms in the preBötzinger complex.The Journal of physiology · 2024Article
- Single cell transcriptome sequencing of inspiratory neurons of the preBötzinger complex in neonatal mice.Scientific data · 2022Article
- Predictions and experimental tests of a new biophysical model of the mammalian respiratory oscillator.eLife · 2022Article
- Dynamics of ramping bursts in a respiratory neuron model.Journal of computational neuroscience · 2022Article
- Transcriptomes of electrophysiologically recorded Dbx1-derived respiratory neurons of the preBötzinger complex in neonatal mice.Scientific reports · 2022Article
- Contributions of h- and NaFrontiers in cellular neuroscience · 2021Article
- Dendritic A-Current in Rhythmically Active PreBötzinger Complex Neurons in Organotypic Cultures from Newborn Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Different roles for inhibition in the rhythm-generating respiratory network.Journal of neurophysiology · 2017Article
- Article
- Mechanisms underlying the activity-dependent regulation of locomotor network performance by the Na+ pump.Scientific reports · 2015Article
- Electrophysiological properties of laryngeal motoneurones in rats submitted to chronic intermittent hypoxia.The Journal of physiology · 2015Article
- Physiological and morphological properties of Dbx1-derived respiratory neurons in the pre-Botzinger complex of neonatal mice.The Journal of physiology · 2013Article
- The cellular building blocks of breathing.Comprehensive Physiology · 2012Review
- Low-threshold calcium currents contribute to locomotor-like activity in neonatal mice.Journal of neurophysiology · 2012Article
- Potassium currents of olfactory bulb juxtaglomerular cells: characterization, simulation, and implications for plateau potential firing.Neuroscience · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
We measured a low-threshold, inactivating K+ current, i.e. A-current (I(A)), in respiratory neurons of the preBötzinger complex (preBötC) in rhythmically active slice preparations from neonatal C57BL/6 mice. The majority of inspiratory neurons (21/34 = 61.8%), but not expiratory neurons (1/8 = 12.5%), expressed I(A). In whole-cell and somatic outside-out patches I(A) activated at -60 mV (half-activation voltage measured -16.3 mV) and only fully inactivated above -40 mV (half-inactivation voltage measured -85.6 mV), indicating that I(A) can influence membrane trajectory at baseline voltages during respiratory rhythm generation in vitro. 4-Aminopyridine (4-AP, 2 mm) attenuated I(A) in both whole-cell and somatic outside-out patches. In the context of rhythmic network activity, 4-AP caused irregular respiratory-related motor output on XII nerves and disrupted rhythmogenesis as detected with whole-cell and field recordings in the preBötC. Whole-cell current-clamp recordings showed that 4-AP changed the envelope of depolarization underlying inspiratory bursts (i.e. inspiratory drive potentials) from an incrementing pattern to a decrementing pattern during rhythm generation and abolished current pulse-induced delayed excitation. These data suggest that I(A) opposes excitatory synaptic depolarizations at baseline voltages of approximately -60 mV and influences the inspiratory burst pattern. We propose that I(A) promotes orderly recruitment of constituent rhythmogenic neurons by minimizing the activity of these neurons until they receive massive coincident synaptic input, which reduces the periodic fluctuations of inspiratory activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.