ArticleThe Journal of physiology2008
'Dynamic' Starling mechanism: effects of ageing and physical fitness on ventricular-arterial coupling.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Acute effects of bolus water intake on post-exercise orthostatic hypotension and cardiovascular hemodynamics.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Trial
- The impact of 2 years of high-intensity exercise training on a model of integrated cardiovascular regulation.The Journal of physiology · 2019Trial
- The effect of 1 year of Alagebrium and moderate-intensity exercise training on left ventricular function during exercise in seniors: a randomized controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Trial
- Mapping the evidence on exercise-related ventricular-arterial coupling adaptations in male adults: a scoping review.Frontiers in cardiovascular medicine · 2026Review
- Pressure applied: Mechanisms affecting heart-lung interactions and cardiac filling in patients with HFpEF during rest and exercise.Heart failure reviews · 2025Review
- Effects of aging and endurance exercise training on cardiorespiratory fitness and cardiac structure and function in healthy midlife and older women.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- The effect of lifelong endurance exercise on cardiovascular structure and exercise function in women.The Journal of physiology · 2020Article
- Exercise and Coronary Atherosclerosis: Observations, Explanations, Relevance, and Clinical Management.Circulation · 2020Review
- Increased Myocardial Stiffness in Patients With High-Risk Left Ventricular Hypertrophy: The Hallmark of Stage-B Heart Failure With Preserved Ejection Fraction.Circulation · 2020Article
- Sex differences in ventricular-vascular coupling following endurance training.European journal of applied physiology · 2014Article
- Pushing the limits: exercise stress in the healthy human heart.The Journal of physiology · 2014Article
- The effect of lifelong exercise dose on cardiovascular function during exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Cardiovascular effects of 1 year of progressive endurance exercise training in patients with heart failure with preserved ejection fraction.American heart journal · 2012Article
- Sex, ageing and resting blood pressure: gaining insights from the integrated balance of neural and haemodynamic factors.The Journal of physiology · 2012Review
- Effect of exercise training on biologic vascular age in healthy seniors.American journal of physiology. Heart and circulatory physiology · 2012Article
- Acute effects of firefighting on cardiac performance.European journal of applied physiology · 2012Article
- Congestive heart failure with preserved ejection fraction is associated with severely impaired dynamic Starling mechanism.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer's disease.Frontiers in neurology · 2011Article
- Cardiac output and oxygen uptake relationship during physical effort in men and women over 60 years old.European journal of applied physiology · 2009Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Cardiovascular diseases increase with advancing age, associated with left ventricular and arterial stiffening in humans. In contrast, daily exercise training prevents and/or improves both ventricular and arterial stiffening with ageing. We propose a new approach to quantify the dynamics of the Starling mechanism, namely the beat-to-beat modulation of stroke volume (SV) caused by beat-to-beat alterations in left ventricular filling, which we propose reflects the complex interaction between ventricular and arterial stiffness. We hypothesized that the dynamic Starling mechanism would be impaired with ageing, and that this impairment would be prevented and restored by daily exercise training. Two different approaches were employed: (1) a cross-sectional study to assess the effects of ageing and life-long exercise training; and (2) a longitudinal study to assess the effects of one-year endurance training in the elderly. Spectral transfer function gain between beat-to-beat changes in left ventricular end-diastolic pressure and SV was used as an index of the dynamic Starling mechanism. Gain was significantly lower in the sedentary elderly (70 +/- 3 years) than in both young individuals (27 +/- 6 years) and Masters athletes (68 +/- 3 years), and it was significantly lower in Masters athletes than in young controls (elderly: 0.37 +/- 0.11; Masters athletes: 0.96 +/- 0.55; young: 1.52 +/- 0.42 ml m(-2) mmHg(-1), mean +/- s.d.). Gain increased by 65% after one-year exercise training in the elderly, although the response was quite variable (P = 0.108). These findings suggest that the dynamic Starling mechanism is impaired with human ageing possibly due to ventricular-arterial stiffening. Life-long daily exercise training may minimize this impairment, although the effect may be limited particularly when started later in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.