ArticleCancer immunology, immunotherapy : CII2008
Sequence uniqueness and sequence variability as modulating factors of human anti-HCV humoral immune response.
Article in Cancer immunology, immunotherapy : CII, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- A survey of k-mer methods and applications in bioinformatics.Computational and structural biotechnology journal · 2024Review
- Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination.Journal of immunology research · 2015Article
- Hepatitis C virus (HCV)-related cryoglobulinemia: cryoglobulin type and anti-HCV profile.Clinical and vaccine immunology : CVI · 2013Article
- Pentamers not found in the universal proteome can enhance antigen specific immune responses and adjuvant vaccines.PloS one · 2012Article
- The self/nonself issue: A confrontation between proteomes.Self/nonself · 2010Article
- Clustering of rare peptide segments in the HCV immunome.Self/nonself · 2010Article
- Proposing low-similarity peptide vaccines against Mycobacterium tuberculosis.Journal of biomedicine & biotechnology · 2010Article
- Bacterial peptides are intensively present throughout the human proteome.Self/nonself · 2010Article
- Proteomic peptide scan of porphyromonas gingivalis fima type ii for searching potential b-cell epitopes.ORAL & implantologyArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
We recently compared the HCV polyprotein to the human proteome in order to test whether amino acid sequences unique to the virus could represent immunodominant epitopic determinants of the human humoral immune response against HCV. We identified a relatively limited number of HCV fragments with no/low similarity to the human host that represented exclusive HCV motifs. In this study, the peptides corresponding to low/zero similarity sequences were synthesized and assayed with HCV-infected sera. With different patterns, the synthetic HCV peptides corresponding to low/zero similarity sequences were found to be immunoreactive. In particular, the HCV E1 (315-323) HRMAWDMMM, HCV E2/NS1 (547-555) NWFGCTWMN, and HCV NS5 (2638-2646) YDTRCFDST sequences were immunodominant in the HCV-infected cohort under study. These three peptides correspond to sequences that are endowed with low-similarity to the human proteome, are highly conserved among various HCV strains, and have, potentially, a scarce susceptibility to proteolytic attacks. These data may be of help in defining the multiple factors which concur in the modulation of the human immune response against HCV, eventually providing information for the design of effective anti-HCV vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.