ArticleThe Journal of clinical investigation1991
Interaction of recombinant apolipoprotein(a) and lipoprotein(a) with macrophages.
Article in The Journal of clinical investigation, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 133 citations in OpenAlex.
- Lipoprotein (a) as a risk factor for prosthetic heart valve thrombosis.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Development and validation of a predictive model for carotid atherosclerosis in postmenopausal women.Scientific reports · 2025Article
- Lipoprotein(a) and Its Role in Peripheral Arterial Disease: A Narrative Review.Vascular health and risk management · 2025Review
- Lipoprotein(a) in Atherosclerotic Diseases: From Pathophysiology to Diagnosis and Treatment.Molecules (Basel, Switzerland) · 2023Review
- A Modern Approach to Dyslipidemia.Endocrine reviews · 2022Article
- Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis.Metabolites · 2021Article
- Lipoprotein (a): Recent Updates on a Unique Lipoprotein.Current atherosclerosis reports · 2021Review
- Recent Updates of Lipoprotein(a) and Cardiovascular Disease.Chonnam medical journal · 2021Review
- Lp(a): Addressing a Target for Cardiovascular Disease Prevention.Current cardiology reports · 2019Review
- Lipids in Children and Links to Adult Vascular Disease.The Clinical biochemist. Reviews · 2018Review
- Plasma anti-α-galactoside antibody mediates lipoprotein(a) binding to macrophages.Glycoconjugate journal · 2016Article
- Oxidized lipoprotein(a) and cardio-ankle vascular index (CAVI) in hypertensive subjects.Heart and vessels · 2013Article
- The relationship between oxidized lipoprotein(a) and carotid atherosclerosis in asymptomatic subjects: a comparison with native lipoprotein(a).Lipids in health and disease · 2011Article
- The association between blood glucose and oxidized lipoprotein(a) in healthy young women.Lipids in health and disease · 2010Article
- Article
- The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor.The Journal of clinical investigation · 1997Article
- Resistance of lipoprotein(a) to lipid peroxidation induced by oxygenated free radicals produced by gamma radiolysis: a comparison with low-density lipoprotein.The Biochemical journal · 1996Article
- The apolipoprotein B3304-3317 peptide as an inhibitor of the lipoprotein (a):apolipoprotein B-containing lipoprotein interaction.The Biochemical journal · 1995Article
- Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia. No evidence for a triglyceride-rich precursor of lipoprotein(a).The Journal of clinical investigation · 1992Article
- Lipoprotein(a)BMJ (Clinical research ed.) · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated plasma levels of lipoprotein(a), Lp(a), represent a major, inherited risk factor for coronary heart disease, although the mechanism of its action remains unknown. Lp(a) is distinguished from the related LDL particle by the addition of apolipoprotein(a), apo(a). The presence of this large glycoprotein is likely to affect the binding of the particle to the LDL receptor and/or other receptors which may contribute to the atherogenic potential of Lp(a). Here we demonstrate the binding to macrophages of Lp(a) and pure recombinant apo(a) protein, via a specific, high-affinity receptor. This binding could lead to foam cell formation and the localization of Lp(a) to atherosclerotic plaques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.