ArticleThe Journal of cell biology1991
Differences between the lateral organization of conventional and inositol phospholipid-anchored membrane proteins. A further definition of micrometer scale membrane domains.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 125 citations in OpenAlex.
- Statin-induced increase in actin polymerization modulates GPCR dynamics and compartmentalization.Biophysical journal · 2023Article
- The Utility of Fluorescence Recovery after Photobleaching (FRAP) to Study the Plasma Membrane.Membranes · 2023Review
- Convergence of lateral dynamic measurements in the plasma membrane of live cells from single particle tracking and STED-FCS.Journal of physics D: Applied physics · 2017Review
- GPI-anchored protein organization and dynamics at the cell surface.Journal of lipid research · 2016Review
- Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse.Frontiers in immunology · 2016Review
- Cytokines Induce Faster Membrane Diffusion of MHC Class I and the Ly49A Receptor in a Subpopulation of Natural Killer Cells.Frontiers in immunology · 2016Article
- Lifetime of major histocompatibility complex class-I membrane clusters is controlled by the actin cytoskeleton.Biophysical journal · 2012Article
- Class I MHC molecules as probes of membrane patchiness: from biophysical measurements to modulation of immune responses.Immunologic research · 2010Review
- Tracking microdomain dynamics in cell membranes.Biochimica et biophysica acta · 2009Review
- What do diffusion measurements tell us about membrane compartmentalisation? Emergence of the role of interprotein interactions.Journal of chemical biology · 2008Article
- Both MHC class II and its GPI-anchored form undergo hop diffusion as observed by single-molecule tracking.Biophysical journal · 2008Article
- Dynamic patches of membrane proteins.Biophysical journal · 2007Article
- Cholesterol dictates the freedom of EGF receptors and HER2 in the plane of the membrane.Biophysical journal · 2005Article
- Ras diffusion is sensitive to plasma membrane viscosity.Biophysical journal · 2005Article
- Dynamics of putative raft-associated proteins at the cell surface.The Journal of cell biology · 2004Article
- Short class I major histocompatibility complex cytoplasmic tails differing in charge detect arbiters of lateral diffusion in the plasma membrane.Biophysical journal · 2004Article
- Lowering the barriers to random walks on the cell surface.Biophysical journal · 2003Article
- Translational diffusion of individual class II MHC membrane proteins in cells.Biophysical journal · 2002Article
- Measurement of the lateral diffusion of human MHC class I molecules on HeLa cells by fluorescence recovery after photobleaching using a phycoerythrin probe.Biophysical journal · 2002Article
- Pulse EPR detection of lipid exchange between protein-rich raft and bulk domains in the membrane: methodology development and its application to studies of influenza viral membrane.Biophysical journal · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Plasma membranes of many cells appear to be divided into domains, areas whose composition and function differ from the average for an entire membrane. We have previously used fluorescence photo-bleaching and recovery to demonstrate one type of membrane domain, with dimensions of micrometers (Yechiel, E., and M. Edidin. 1987, J. Cell Biol. 105: 755-760). The presence of membrane domains is inferred from the dependence of the apparent mobile fraction of labeled molecules on the size of the membrane area probed. We now find that by this definition classical class I MHC molecules, H-2Db, are concentrated in domains in the membranes of K78-2 hepatoma cells, while the nonclassical class I-related molecules, Qa-2, are free to pass the boundaries of these domains. The two proteins are highly homologous but differ in their mode of anchorage to the membrane lipid bilayer. H-2Db is anchored by a transmembrane peptide, while Qa-2 is anchored by a glycosylphosphatidylinositol (GPI) anchor. A mutant class I protein with its external portion derived from Qa-2 but with transmembrane and cytoplasmic sequences from a classical class I molecule shows a dependence of its mobile fraction on the area of membrane probed, while a mutant whose external portions are a mixture of classical and nonclassical class I sequences, GPI-linked to the bilayer, does not show this dependence and hence by our definition is not restricted to membrane domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.