ArticleMolecular biology of the cell2008
The chicken yolk sac IgY receptor, a mammalian mannose receptor family member, transcytoses IgY across polarized epithelial cells.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- H9N2 Avian Influenza Virus Downregulates FcRY Expression in Chicken Macrophage Cell Line HD11 by Activating the JNK MAPK Pathway.International journal of molecular sciences · 2024Article
- FcRY is a key molecule controlling maternal blood IgY transfer to yolks during egg development in avian species.Frontiers in immunology · 2024Article
- IgYs: on her majesty's secret service.Frontiers in immunology · 2023Review
- Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Haemagglutinin antigen selectively targeted to chicken CD83 overcomes interference from maternally derived antibodies in chickens.NPJ vaccines · 2022Article
- Centennial Review: The chicken yolk sac is a multifunctional organ.Poultry science · 2021Review
- Evaluation of the Immunogenic Response of a Novel Enterobactin Conjugate Vaccine in Chickens for the Production of Enterobactin-Specific Egg Yolk Antibodies.Frontiers in immunology · 2021Article
- Maternally-Derived Antibodies Protect against Challenge with Highly Pathogenic Avian Influenza Virus of the H7N3 Subtype.Vaccines · 2019Article
- The Neonatal Fc Receptor (FcRn): A Misnomer?Frontiers in immunology · 2019Review
- Article
- Passive immunisation, an old idea revisited: Basic principles and application to modern animal production systems.Veterinary immunology and immunopathology · 2016Review
- Chicken IgY Fc expressed by Eimeria mitis enhances the immunogenicity of E. mitis.Parasites & vectors · 2016Article
- The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review).International journal of oncology · 2015Review
- Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics.Critical reviews in biotechnology · 2015Review
- Membranous nephropathy: from models to man.The Journal of clinical investigation · 2014Review
- Evolution of an expanded mannose receptor gene family.PloS one · 2014Article
- Recombinant proteins produced into yolk of genetically manipulated chickens are partly sialylated in N-glycan.Cytotechnology · 2013Article
- Correlation analysis of the total IgY level in hen serum, egg yolk and offspring serum.Journal of animal science and biotechnology · 2013Article
- Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances.Advanced drug delivery reviews · 2013Review
- Avian IgY antibodies and their recombinant equivalents in research, diagnostics and therapy.Biologicals : journal of the International Association of Biological Standardization · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In mammals the transfer of passive immunity from mother to young is mediated by the MHC-related receptor FcRn, which transports maternal IgG across epithelial cell barriers. In birds, maternal IgY in egg yolk is transferred across the yolk sac to passively immunize chicks during gestation and early independent life. The chicken yolk sac IgY receptor (FcRY) is the ortholog of the mammalian phospholipase A2 receptor, a mannose receptor family member, rather than an FcRn or MHC homolog. FcRn and FcRY both exhibit ligand binding at the acidic pH of endosomes and ligand release at the slightly basic pH of blood. Here we show that FcRY expressed in polarized mammalian epithelial cells functioned in endocytosis, bidirectional transcytosis, and recycling of chicken FcY/IgY. Confocal immunofluorescence studies demonstrated that IgY binding and endocytosis occurred at acidic but not basic pH, mimicking pH-dependent uptake of IgG by FcRn. Colocalization studies showed FcRY-mediated internalization via clathrin-coated pits and transport involving early and recycling endosomes. Disruption of microtubules partially inhibited apical-to-basolateral and basolateral-to-apical transcytosis, but not recycling, suggesting the use of different trafficking machinery. Our results represent the first cell biological evidence of functional equivalence between FcRY and FcRn and provide an intriguing example of how evolution can give rise to systems in which similar biological requirements in different species are satisfied utilizing distinct protein folds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.