ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Light adaptation in salamander L-cone photoreceptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Predicting and Manipulating Cone Responses to Naturalistic Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Impact of light-adaptive mechanisms on mammalian retinal visual encoding at high light levels.Journal of neurophysiology · 2018Article
- LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors.Cell reports · 2018Article
- Rhodopsin kinase and recoverin modulate phosphodiesterase during mouse photoreceptor light adaptation.The Journal of general physiology · 2015Article
- Activation and quenching of the phototransduction cascade in retinal cones as inferred from electrophysiology and mathematical modeling.Molecular vision · 2015Article
- Extracellular ATP hydrolysis inhibits synaptic transmission by increasing ph buffering in the synaptic cleft.PLoS biology · 2014Article
- EML1 (CNG-modulin) controls light sensitivity in darkness and under continuous illumination in zebrafish retinal cone photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Disease-associated mutations in CNGB3 promote cytotoxicity in photoreceptor-derived cells.Molecular vision · 2013Article
- Dynamical adaptation in photoreceptors.PLoS computational biology · 2013Article
- Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models.Progress in retinal and eye research · 2012Review
- Light-driven calcium signals in mouse cone photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Speed, adaptation, and stability of the response to light in cone photoreceptors: the functional role of Ca-dependent modulation of ligand sensitivity in cGMP-gated ion channels.The Journal of general physiology · 2012Article
- Adaptation of mammalian photoreceptors to background light: putative role for direct modulation of phosphodiesterase.Molecular neurobiology · 2011Review
- Biophysical mechanisms underlying olfactory receptor neuron dynamics.Nature neuroscience · 2011Article
- Channel modulation and the mechanism of light adaptation in mouse rods.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Photopigment quenching is Ca2+ dependent and controls response duration in salamander L-cone photoreceptors.The Journal of general physiology · 2010Article
- Cones perform a non-linear transformation on natural stimuli.The Journal of physiology · 2010Article
- Rod phototransduction determines the trade-off of temporal integration and speed of vision in dark-adapted toads.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The responses of individual salamander L-cones to light steps of moderate intensity (bleaching 0.3-3% of the total photopigment) and duration (between 5 and 90 s) were recorded using suction electrodes. Light initially suppressed the circulating current, which partially recovered or "sagged" over several seconds. The sensitivity of the cone to dim flashes decreased rapidly after light onset and approached a minimum within 500 ms. Background light did not affect the rising phase of the dim flash response, a measure of the initial gain of phototransduction. When the light was extinguished, the circulating current transiently exceeded or "overshot" its level in darkness. During the overshoot, the sensitivity of the cone required several seconds to recover. The sag and overshoot remained in voltage-clamped cones. Comparison with theory suggests that three mechanisms cause the sag, overshoot, and slow recovery of sensitivity after the light step: a gradual increase in the rate of inactivation of the phototransduction cascade during the light step, residual activity of the transduction cascade after the step is extinguished, and an increase in guanylate cyclase activity during the light step that persists after the light is extinguished.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.