Evidence map›Paper›PMID 18256137›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008

Regulation of Fto/Ftm gene expression in mice and humans.

George Stratigopoulos, Stephanie L Padilla, Charles A LeDuc, Elizabeth Watson, Andrew T Hattersley, Mark I McCarthy, Lori M Zeltser, Wendy K Chung, Rudolph L Leibel

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 154 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 6 pooled it
22.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 6 syntheses or guidelines pooled it, 328 citations in OpenAlex.

  1. Pooled it
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  5. Association between FTO gene polymorphism and cancer risk: evidence from 16,277 cases and 31,153 controls.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012
    Pooled it
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  14. mCell stem cell · 2025
    Article
  15. The therapeutic potential of RNA m(6)A in lung cancer.Cell communication and signaling : CCS · 2024
    Review
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  17. Article
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94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

George StratigopoulosDivision of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA.
Stephanie L Padilla
Charles A LeDuc
Elizabeth Watson
Andrew T Hattersley
Mark I McCarthy
Lori M Zeltser
Wendy K Chung
Rudolph L Leibel
Columbia University · US

Funding

The molecular genetic analysis of human obesityR01DK052431 · NIDDK · ROCKEFELLER UNIVERSITY · PI CHUNG, WENDY K, LEIBEL, RUDOLPH L · 1996 to 2020
$11.6M
Leptin in Human Energy and Neuroendocrine HomeostasisR01DK064773 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEIBEL, RUDOLPH L · 2003 to 2013
$3.3M
NIDDK NIH HHS P30-DK6687-06NIDDK NIH HHS R01 DK052431NIDDK NIH HHS R01 DK064773NIDDK NIH HHS R-01-DK52431-15Wellcome Trust
6 · The paper itself

Abstract

Two recent, large whole-genome association studies (GWAS) in European populations have associated a approximately 47-kb region that contains part of the FTO gene with high body mass index (BMI). The functions of FTO and adjacent FTM in human biology are not clear. We examined expression of these genes in organs of mice segregating for monogenic obesity mutations, exposed to underfeeding/overfeeding, and to 4 degrees C. Fto/Ftm expression was reduced in mesenteric adipose tissue of mice segregating for the Ay, Lep ob, Lepr db, Cpe fat, or tub mutations, and there was a similar trend in other tissues. These effects were not due to adiposity per se. Hypothalamic Fto and Ftm expression were decreased by fasting in lean and obese animals and by cold exposure in lean mice. The fact that responses of Fto and Ftm expression to these manipulations were almost indistinguishable suggested that the genes might be coregulated. The putative overlapping regulatory region contains at least two canonical CUTL1 binding sites. One of these nominal CUTL1 sites includes rs8050136, a SNP associated with high body mass. The A allele of rs8050136 preferentially bound CUTL1[corrected] in human fibroblast DNA. 70% knockdown of CUTL1 expression in human fibroblasts decreased FTO and FTM expression by 90 and 65%, respectively. Animals and humans with various genetic interruptions of FTO or FTM have phenotypes reminiscent of aspects of the Bardet-Biedl obesity syndrome, a confirmed "ciliopathy." FTM has recently been shown to be a ciliary basal body protein.

Indexed as

Gene Expression RegulationPolymorphism, Single NucleotideAdaptor Proteins, Signal TransducingAdipocytesAdipose TissueAdiposityAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnimalsBardet-Biedl SyndromeCells, CulturedCytoskeletal ProteinsDisease Models, AnimalEatingEmbryo, MammalianEnergy MetabolismFastingAdaptor Proteins, Signal TransducingAlpha-Ketoglutarate-Dependent Dioxygenase FTOCUX1 protein, humanCytoskeletal ProteinsFtm protein, mouseFTO protein, humanFTO protein, mouseHomeodomain ProteinsLeptinMixed Function OxygenasesNuclear ProteinsOxo-Acid-LyasesProteinsRepressor ProteinsRNA, MessengerRPGRIP1 protein, humanTranscription Factors

Identifiers

PMID18256137
PMCPMC2808712
OpenAlexW2169648564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.