ArticleThe Journal of biological chemistry2008
Pepsinogen C proteolytic processing of surfactant protein B.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Homo- and hetero-oligomerization of hydrophobic pulmonary surfactant proteins SP-B and SP-C in surfactant phospholipid membranes.The Journal of biological chemistry · 2018Article
- When Is an Alveolar Type 2 Cell an Alveolar Type 2 Cell? A Conundrum for Lung Stem Cell Biology and Regenerative Medicine.American journal of respiratory cell and molecular biology · 2017Review
- Pepsinogen C expression, regulation and its relationship with cancer.Cancer cell international · 2017Review
- Antiinflammatory Effects of Budesonide in Human Fetal Lung.American journal of respiratory cell and molecular biology · 2016Article
- Clinical Utility of Bronchoalveolar Lavage Pepsin in Diagnosis of Gastroesophageal Reflux among Wheezy Infants.Canadian respiratory journal · 2016Article
- Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis.Cancer cell · 2013Article
- Article
- Biomarkers for gastroesophageal reflux in respiratory diseases.Gastroenterology research and practice · 2013Article
- Prenatal antiepileptic exposure associates with neonatal DNA methylation differences.Epigenetics · 2012Article
- The presence of pepsin in the lung and its relationship to pathologic gastro-esophageal reflux.Neurogastroenterology and motility · 2012Article
- The effect of interleukin-13 (IL-13) and interferon-γ (IFN-γ) on expression of surfactant proteins in adult human alveolar type II cells in vitro.Respiratory research · 2010Article
- Regulated gene expression in cultured type II cells of adult human lung.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- Opposing regulation of human alveolar type II cell differentiation by nitric oxide and hyperoxia.Pediatric research · 2010Article
- RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation.Molecular and cellular biology · 2010Article
- C/EBP{alpha} is required for pulmonary cytoprotection during hyperoxia.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases.The Journal of biological chemistry · 2009Article
- Carcinoembryonic cell adhesion molecule 6 in human lung: regulated expression of a multifunctional type II cell protein.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Posttranslational regulation of surfactant protein B expression.Seminars in perinatology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Surfactant protein B (SP-B) is essential to the function of pulmonary surfactant and to lamellar body genesis in alveolar epithelial type 2 cells. The bioactive, mature SP-B is derived from multistep post-translational proteolysis of a larger proprotein. The identity of the proteases involved in carboxyl-terminal cleavage of proSP-B remains uncertain. This cleavage event distinguishes SP-B production in type 2 cells from less complete processing in bronchiolar Clara cells. We previously identified pepsinogen C as an alveolar type 2 cell-specific protease that was developmentally regulated in the human fetal lung. We report that pepsinogen C cleaved recombinant proSP-B at Met(302) in addition to an amino-terminal cleavage at Ser(197). Using a well described model of type 2 cell differentiation, small interfering RNA knockdown of pepsinogen C inhibited production of mature SP-B, whereas overexpression of pepsinogen C increased SP-B production. Inhibition of SP-B production recapitulated the SP-B-deficient phenotype evident by aberrant lamellar body genesis. Together, these data support a primary role for pepsinogen C in SP-B proteolytic processing in alveolar type 2 cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.