Evidence map›Paper›PMID 18255277›Full record

ReviewCurrent opinion in structural biology2008

Towards deciphering the principles underlying an mRNA recognition code.

Alexander Serganov, Dinshaw J Patel

Abstract readReview
In one paragraph

Review in Current opinion in structural biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Structural mechanism for HIV-1 TAR loop recognition by Tat and the super elongation complex.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. An overview of RNAs with regulatory functions in gram-positive bacteria.Cellular and molecular life sciences : CMLS · 2010
    Review
  14. Review
  15. The long and the short of riboswitches.Current opinion in structural biology · 2009
    Review
  16. Studying membrane proteins through the eyes of the genetic code revealed a strong uracil bias in their coding mRNAs.Proceedings of the National Academy of Sciences of the United States of America · 2009
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexander SerganovStructural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. serganoa@mskcc.org
Dinshaw J Patel
Memorial Sloan Kettering Cancer Center · US

Funding

TUMORIGENIC DNA DAMAGE AND PEPTIDE-RNA RECOGNITIONR01CA049982 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PATEL, DINSHAW J · 1990 to 2008
$2.6M
RNA REGULATORY DOMAINS: FOLDING, RECOGNITION &CATALYSISR01GM073618 · NIGMS · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PATEL, DINSHAW J · 2005 to 2008
$1.3M
NCI NIH HHS CA049982NCI NIH HHS R01 CA049982NIGMS NIH HHS GM073618NIGMS NIH HHS R01 GM073618
6 · The paper itself

Abstract

Messenger RNAs interact with a number of different molecules that determine the fate of each transcript and contribute to the overall pattern of gene expression. These interactions are governed by specific mRNA signals, which in principle could represent a special mRNA recognition 'code'. Both, small molecules and proteins demonstrate a diversity of mRNA binding modes often dependent on the structural context of the regions surrounding specific target sequences. In this review, we have highlighted recent structural studies that illustrate the diversity of recognition principles used by mRNA binders for timely and specific targeting and processing of the message.

Indexed as

AnimalsBase SequenceBinding SitesHumansModels, BiologicalModels, MolecularMolecular Sequence DataNucleic Acid ConformationProtein ConformationRNA-Binding ProteinsRNA, MessengerRNA Processing, Post-TranscriptionalRNA-Binding ProteinsRNA, Messenger

Identifiers

PMID18255277
PMCPMC3744885
OpenAlexW2056588197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.