ArticleBiomaterials2008
The effect of local simvastatin delivery strategies on mandibular bone formation in vivo.
Article in Biomaterials, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 98 citations in OpenAlex.
- P. gingivalis-host interactions direct antibiotic adjuvants for periodontitis antimicrobial therapy.International journal of oral science · 2026Article
- Histomorphometric Evaluation of Socket Preservation Healing Using Xenogeneic Bone Substitute Combined with Statin: A Prospective Split-Mouth Clinical Pilot Study.Acta stomatologica Croatica · 2026Article
- The local application of a 1% simvastatin gel improves bone regeneration in osteoporotic mandibular defects: a rat model study.Annals of medicine and surgery (2012) · 2025Article
- Radiographic Evaluation of Reparative Dentin Formation after Direct Pulp Capping Using Rosuvastatin vs Mineral Trioxide Aggregate on Young Mature Permanent Molar-90 Days of Follow-up: A Split-mouth Study.International journal of clinical pediatric dentistry · 2024Article
- Effects of Simvastatin-Loaded Nanomicelles on the Early Preservation of Tooth Extraction Sites.International journal of nanomedicine · 2024Article
- The evaluation of cytotoxicity and cytokine IL-6 production of root canal sealers with and without the incorporation of simvastatin: an invitro study.BMC oral health · 2022Article
- The effect of topical administration of simvastatin on entochondrostosis and intramembranous ossification: An animal experiment.Journal of orthopaedic translation · 2021Article
- Comparison the effects of chitosan and hyaluronic acid-based thermally sensitive hydrogels containing rosuvastatin on human osteoblast-like MG-63 cells.Research in pharmaceutical sciences · 2020Article
- Biodegradable polymerized simvastatin stimulates bone formation.Acta biomaterialia · 2019Article
- Local Application of Pyrophosphorylated Simvastatin Prevents Experimental Periodontitis.Pharmaceutical research · 2018Article
- Combination of simvastatin, calcium silicate/gypsum, and gelatin and bone regeneration in rabbit calvarial defects.Scientific reports · 2016Article
- A single CT-guided percutaneous intraosseous injection of thermosensitive simvastatin/poloxamer 407 hydrogel enhances vertebral bone formation in ovariectomized minipigs.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Local delivery of controlled-release simvastatin to improve the biocompatibility of polyethylene terephthalate artificial ligaments for reconstruction of the anterior cruciate ligament.International journal of nanomedicine · 2016Article
- Role of MSX1 in Osteogenic Differentiation of Human Dental Pulp Stem Cells.Stem cells international · 2016Article
- Single-dose local simvastatin injection improves implant fixation via increased angiogenesis and bone formation in an ovariectomized rat model.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Simvastatin prodrug micelles target fracture and improve healing.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy.Journal of translational medicine · 2014Article
- Highly efficient release of simvastatin from simvastatin-loaded calcium sulphate scaffolds enhances segmental bone regeneration in rabbits.Molecular medicine reports · 2014Article
- Platelet-rich plasma, plasma rich in growth factors and simvastatin in the regeneration and repair of alveolar bone.Experimental and therapeutic medicine · 2013Article
- Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells.The AAPS journal · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Systemic simvastatin is known to reduce cholesterol and stimulate modest bone formation, but local surgical placement in polylactic acid domes causes robust bone formation and local swelling. A less invasive and more flexible injection protocol was studied to evaluate the bone-inducing effects compared to surgical implantation. Bone formation rate, short- and long-term bone augmentation histology, and mechanical properties were evaluated to characterize the new bone in a rat bilateral mandible model (test and control sides in same animal). Results demonstrated that multiple (3) injections of 0.5 mg simvastatin effectively reduced soft tissue swelling while preserving bone growth (60% increase of bone width at 24 days) compared to simvastatin dome placement (43% increase at 24 days). Compared to controls, bone formation rate was significantly higher on the simvastatin side, especially in the dome. Three-point bending tests revealed higher maximum force to fracture and stiffness at 24 days with simvastatin injections. Long-term evaluation showed that 55% of maximum new bone formed 24 days post-injection was retained at 90 days.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.