ArticleBMC evolutionary biology2008
Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- Age-associated changes in the shell gland transcriptomics and eggshell quality of broiler breeder hens.BMC genomics · 2026Article
- Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface.Nature communications · 2025Article
- Differential susceptibility to prenatal stress exposure in serotonin transporter-deficient female mice-an epigenetic exploration.Frontiers in neuroscience · 2025Article
- Gating elements for carvacrol activation of the OTOP1 proton channel.Communications biology · 2024Article
- Structural mechanism of proton conduction in otopetrin proton channel.Nature communications · 2024Article
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- Acid and Alkali Taste Sensation.Metabolites · 2023Review
- Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus.eLife · 2023Article
- Vertebrate OTOP1 is also an alkali-activated channel.Nature communications · 2023Article
- Nematode homologs of the sour taste receptor Otopetrin1 are evolutionarily conserved acid-sensitive proton channels.Frontiers in cell and developmental biology · 2023Article
- The Cellular and Molecular Basis of Sour Taste.Annual review of physiology · 2022Review
- Mechanisms for the Sour Taste.Handbook of experimental pharmacology · 2022Article
- Requirement for an Otopetrin-like protein for acid taste inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Sour taste: receptors, cells and circuits.Current opinion in physiology · 2021Article
- Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population.Scientific reports · 2020Article
- Otopetrin-2 Immunolocalization in the Human Macula Utricle.The Annals of otology, rhinology, and laryngology · 2019Article
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- Wild-type p53 regulates OTOP2 transcription through DNA loop alteration of the promoter in colorectal cancer.FEBS open bio · 2019Article
- An evolutionarily conserved gene family encodes proton-selective ion channels.Science (New York, N.Y.) · 2018Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOtopetrin 1 (Otop1) encodes a multi-transmembrane domain protein with no homology to known transporters, channels, exchangers, or receptors. Otop1 is necessary for the formation of otoconia and otoliths, calcium carbonate biominerals within the inner ear of mammals and teleost fish that are required for the detection of linear acceleration and gravity. Vertebrate Otop1 and its paralogues Otop2 and Otop3 define a new gene family with homology to the invertebrate Domain of Unknown Function 270 genes (DUF270; pfam03189).
resultsMulti-species comparison of the predicted primary sequences and predicted secondary structures of 62 vertebrate otopetrin, and arthropod and nematode DUF270 proteins, has established that the genes encoding these proteins constitute a single family that we renamed the Otopetrin Domain Protein (ODP) gene family. Signature features of ODP proteins are three "Otopetrin Domains" that are highly conserved between vertebrates, arthropods and nematodes, and a highly constrained predicted loop structure.
conclusionOur studies suggest a refined topologic model for ODP insertion into the lipid bilayer of 12 transmembrane domains, and highlight conserved amino-acid residues that will aid in the biochemical examination of ODP family function. The high degree of sequence and structural similarity of the ODP proteins may suggest a conserved role in the intracellular trafficking of calcium and the formation of biominerals.
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