ArticleNeural computation2008
Effects of synaptic synchrony on the neuronal input-output relationship.
Article in Neural computation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development.Immunity · 2024Article
- The Impact of Multivesicular Release on the Transmission of Sensory Information by Ribbon Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Estimating cortical column sensory networks in rodents from micro-electrocorticograph (μECoG) recordings.NeuroImage · 2017Article
- Modulation of hippocampal rhythms by subthreshold electric fields and network topology.Journal of computational neuroscience · 2013Article
- The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes.Nature reviews. Neuroscience · 2012Review
- Feed-forward inhibition as a buffer of the neuronal input-output relation.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The firing rate of individual neurons depends on the firing frequency of their distributed synaptic inputs, with linear and nonlinear relations subserving different computational functions. This letter explores the relationship between the degree of synchrony among excitatory synapses and the linearity of the response using detailed compartmental models of cortical pyramidal cells. Synchronous input resulted in a linear input-output relationship, while asynchronous stimulation yielded sub- and supraproportional outputs at low and high frequencies, respectively. The dependence of input-output linearity on synchrony was sigmoidal and considerably robust with respect to dendritic location, stimulus irregularity, and alteration of active and synaptic properties. Moreover, synchrony affected firing rate differently at lower and higher input frequencies. A reduced integrate-and-fire model suggested a mechanism explaining these results based on spatiotemporal integration, with fundamental implications relating synchrony to memory encoding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.