ReviewPediatric nephrology (Berlin, Germany)2008
Gene discovery and vesicoureteric reflux.
Review in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Clinical characteristics of primary vesicoureteral reflux in children with an allergic constitution.European journal of medical research · 2024Article
- Human and mouse studies establish TBX6 in Mendelian CAKUT and as a potential driver of kidney defects associated with the 16p11.2 microdeletion syndrome.Kidney international · 2020Article
- Morphological study of the ureterovesical junction in children.Journal of anatomy · 2018Article
- Loss of peri-Wolffian duct stromal Frs2α expression in mice leads to abnormal ureteric bud induction and vesicoureteral reflux.Pediatric research · 2017Article
- Modulation of apoptotic response by LAR family phosphatases-cIAP1 signaling during urinary tract morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Estimation of the relationship between the polymorphisms of selected genes: ACE, AGTR1, TGFβ1 and GNB3 with the occurrence of primary vesicoureteral reflux.International urology and nephrology · 2017Article
- Genetics of Vesicoureteral Reflux.Current genomics · 2016Article
- Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in mice.Development (Cambridge, England) · 2012Article
- 3-Dimensional morphometric analysis of murine bladder development and dysmorphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Genes in the ureteric budding pathway: association study on vesico-ureteral reflux patients.PloS one · 2012Article
- Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium.Developmental biology · 2011Article
- Genetics of vesicoureteral reflux.Nature reviews. Urology · 2011Review
- Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice.Development (Cambridge, England) · 2011Article
- Assessing vesicoureteral reflux in live inbred mice via ultrasound with a microbubble contrast agent.American journal of physiology. Renal physiology · 2011Article
- Primary, nonsyndromic vesicoureteric reflux and nephropathy in sibling pairs: a United Kingdom cohort for a DNA bank.Clinical journal of the American Society of Nephrology : CJASN · 2011Article
- Noninvasive assessment of antenatal hydronephrosis in mice reveals a critical role for Robo2 in maintaining anti-reflux mechanism.PloS one · 2011Article
- Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2.PloS one · 2011Article
- High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma.The Journal of urology · 2010Article
- Lower urinary tract development and disease.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vesicoureteric reflux (VUR) is a congenital urinary tract defect caused by abnormal insertion of the ureter within the bladder wall. This leads to a defective ureterovesical junction in which urine flows retrogradely from the bladder to the kidneys. Although VUR is associated with recurrent urinary tract infections, renal malformations, hypertension, and reflux nephropathy, its relationship to each of these clinical entities is poorly understood. Mutations in genes expressed by the developing kidney and urinary tract can cause VUR in mice, and some of these same genes have been identified in humans with VUR. By discovering the genes that are associated with VUR, new hypotheses will be generated such that, eventually, the relationship between VUR and its complications will be understood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.