ArticlePediatric nephrology (Berlin, Germany)2008
Development of an experimental hemolytic uremic syndrome in rats.
Article in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Eliglustat prevents acute kidney injury caused by Shiga toxin 2 in lethal and sublethal rat models of hemolytic uremic syndrome.Frontiers in pharmacology · 2026Article
- Review
- A One Health Perspective for Defining and DecipheringComparative medicine · 2021Review
- Acute kidney injury caused by venomous animals: inflammatory mechanisms.The journal of venomous animals and toxins including tropical diseases · 2021Article
- Relevance of Bacteriophage 933W in the Development of Hemolytic Uremic Syndrome (HUS).Frontiers in microbiology · 2018Article
- Bacterial Chat: Intestinal Metabolites and Signals in Host-Microbiota-Pathogen Interactions.Infection and immunity · 2017Review
- Effects of Escherichia coli subtilase cytotoxin and Shiga toxin 2 on primary cultures of human renal tubular epithelial cells.PloS one · 2014Article
- Advances in the development of enterohemorrhagic Escherichia coli vaccines using murine models of infection.Vaccine · 2013Review
- Shiga toxins and the pathophysiology of hemolytic uremic syndrome in humans and animals.Toxins · 2012Review
- Microalbuminuria and early renal response to lethal dose Shiga toxin type 2 in rats.International journal of nephrology and renovascular disease · 2012Article
- Shiga toxin subtypes display dramatic differences in potency.Infection and immunity · 2011Article
- Mouse models of Escherichia coli O157:H7 infection and shiga toxin injection.Journal of biomedicine & biotechnology · 2011Review
- Role of nitric oxide in shiga toxin-2-induced premature delivery of dead fetuses in rats.PloS one · 2010Article
- Introduction: education teaching article series on hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Escherichia coli strains producing Shiga toxins (Stxs) colonize the lower gastrointestinal tract and cause watery diarrhea, hemorrhagic colitis, and hemolytic-uremic syndrome (HUS). HUS is characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Oliguria associated with acute tubular necrosis and microangiopathic thrombosis has been reported as the most common cause of renal failure in Argentinean children. Our study was undertaken to obtain a model of HUS in rats that was similar to the clinical and renal histopathology findings described in humans. Rats were intraperitoneally inoculated with culture supernatant from recombinant E. coli expressing Stx2. Glomerular filtrate volume evaluated from clearance of creatinine resulted in a progressive reduction (from 53% at 24 h to 90% at 48 h). Urine volume increased significantly at 24 h but returned to normal levels at 48 h. Evidence of thrombocytopenia, anemia and leukocytosis was documented. Macroscopic analysis revealed a hyperemic peritoneal face with intestinal water accumulation. The kidneys were friable and congestive. Histopathological analysis showed glomerular and tubular necrosis as well as microangiopathic thrombosis. Our findings indicated vascular damage and kidney lesions similar to those described in humans with HUS.
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Registered trials
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