ArticleImmunogenetics2008
Evolution of Crohn's disease-associated Nod2 mutations.
Article in Immunogenetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Crohn's Disease: Is the Cold Chain Hypothesis Still Hot?Journal of Crohn's & colitis · 2021Review
- Relationship(s) between obesity and inflammatory bowel diseases: possible intertwined pathogenic mechanisms.Clinical journal of gastroenterology · 2020Review
- Comparative United States autoimmune disease rates for 2010-2016 by sex, geographic region, and race.Autoimmunity reviews · 2020Review
- Periodontal Infectogenomics.Inflammation and regeneration · 2018Review
- NOD2/CARD15 gene mutations in North Algerian patients with inflammatory bowel disease.World journal of gastroenterology · 2015Article
- Adult lactose digestion status and effects on disease.Canadian journal of gastroenterology & hepatology · 2015Review
- Association between NOD2/CARD15 gene polymorphisms and Crohn's disease in Chinese Zhuang patients.World journal of gastroenterology · 2014Article
- Latitude, sunshine, and human lactase phenotype distributions may contribute to geographic patterns of modern disease: the inflammatory bowel disease model.Clinical epidemiology · 2014Article
- Common NOD2 risk variants in African Americans with Crohn's disease are due exclusively to recent Caucasian admixture.Inflammatory bowel diseases · 2012Article
- Confirmation of three inflammatory bowel disease susceptibility loci in a Chinese cohort.International journal of colorectal disease · 2012Article
- A novel single nucleotide polymorphism within the NOD2 gene is associated with pulmonary tuberculosis in the Chinese Han, Uygur and Kazak populations.BMC infectious diseases · 2012Article
- Cutting edge: Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- NOD2 mutations and anti-Saccharomyces cerevisiae antibodies are risk factors for Crohn's disease in African Americans.The American journal of gastroenterology · 2010Article
- First description of NOD2 variant associated with defective neutrophil responses in a woman with granulomatous mastitis related to corynebacteria.Journal of clinical microbiology · 2009Article
- Article
- Detection of mutations inSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several lines of evidence have confirmed the importance of Nod2 mutations for disease susceptibility in Crohn's disease. For tracing Nod2 evolution, exons 4a, 4e, 8, and 12 mutations were screened in a collection of 1,064 DNA samples from 52 worldwide populations. The overall allele frequency was 7.5% for single nucleotide polymorphism (SNP)5, 0.2% for SNP8, 0.3% for SNP12, and 0.4% for SNP13. Nod2 mutations are mainly Caucasian alleles with strong distribution dissimilarity between single populations and major geographical regions. This regional diversity of Nod2 mutations within Europe points to the regional existence of selection pressure (possibly through dairy-associated bacterial infections within Neolithic cattle farming populations). The SNP5 gradient between Africa and the Middle East and its absence in Asian and Native American populations indicate that the evolution of this variant occurred in the Middle East. As mutations in exons 4e, 8, and 12 were only found in association with SNP5, this variant may have allowed selection pressure to arise.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.