ArticleImmunogenetics2008
Genomic organisation and allelic diversity within coding and non-coding regions of the Ovar-DRB1 locus.
Article in Immunogenetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- First molecular insight intoVeterinary world · 2025Article
- Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing.BMC genomics · 2024Article
- Association of Ovar-DRB1 alleles with innate immune responses in sheep.Veterinary medicine and science · 2022Article
- A chromosome-scale reference genome and genome-wide genetic variations elucidate adaptation in yak.Molecular ecology resources · 2021Article
- Molecular Cloning and Bioinformatics Analysis ofInternational journal of molecular sciences · 2019Article
- Structural and functional diversity arising from intra- and inter-haplotype combinations of duplicated DQA and B loci within the ovine MHC.Immunogenetics · 2018Article
- Genetic characterization of some Turkish sheep breeds based on the sequencing of theArchives animal breeding · 2018Article
- A quick and robust MHC typing method for free-ranging and captive primate species.Immunogenetics · 2017Article
- The genetic architecture of the MHC class II region in British Texel sheep.Immunogenetics · 2017Article
- MHC-DRB1/DQB1 Gene Polymorphism and Its Association with Resistance/Susceptibility to Cystic Echinococcosis in Chinese Merino Sheep.Journal of parasitology research · 2014Article
- A physical map of a BAC clone contig covering the entire autosome insertion between ovine MHC Class IIa and IIb.BMC genomics · 2012Article
- A complete DNA sequence map of the ovine major histocompatibility complex.BMC genomics · 2010Article
- Trans-species polymorphism and selection in the MHC class II DRA genes of domestic sheep.PloS one · 2010Article
- Sequence-based genotyping of the sheep MHC class II DRB1 locus.Immunogenetics · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In all but the most primitive vertebrates, multiple polymorphic genes associated with lymphocyte-mediated immunological surveillance are linked together within genomic regions termed the major histocompatibility complex (MHC). The extensive diversity at many MHC loci provides a valuable source of genetic markers for examining the complex relationships between host genotype and disease resistance or susceptibility. Such studies in domestic sheep (Ovis aries) have generally focused on exon 2 of the polymorphic class II MHC DRB1 gene and its adjacent sequences. We have determined the complete genomic sequences of two Ovar-DRB1 alleles, which has allowed an analysis of diversity at coding, non-coding and promoter regions of this gene. On the basis of these sequences, oligonucleotide primers were designed for amplification of full-length Ovar-DRB1 transcripts and used to evaluate diversity within an MHC-defined resource flock maintained at the Moredun Institute. We describe nine novel full-length Ovar-DRB1 sequences along with an improved direct-sequencing method for analysis of the entire exon 2 region of the Ovar-DRB1 gene based on previously unknown intronic sequences. We discuss how these data provide evidence on the evolution of MHC DRB diversity in domestic sheep.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.