ArticleDie Naturwissenschaften2008
One-step formation of oligopeptide-like molecules from Glu and Asp in hydrothermal environments.
Article in Die Naturwissenschaften, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 29 citations in OpenAlex.
- Nano-pulsed discharge plasma-induced abiotic oligopeptide formation from diketopiperazine.Die Naturwissenschaften · 2022Article
- Hydrothermal Microflow Technology as a Research Tool for Origin-of-Life Studies in Extreme Earth Environments.Life (Basel, Switzerland) · 2017Review
- Phosphorylation of human calsequestrin: implications for calcium regulation.Molecular and cellular biochemistry · 2011Article
- The organic composition of carbonaceous meteorites: the evolutionary story ahead of biochemistry.Cold Spring Harbor perspectives in biology · 2010Review
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2 authors at 1 institution in 1 country.
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Abstract
Biopolymer accumulation in the absence of enzymes is an essential step for the chemical evolution of primitive life-like systems, and successful simulation experiments of prebiotic biopolymer formation have suggested that oligopeptides could have formed near submarine hydrothermal vent environments on primitive earth. However, the yield and length of oligopeptides -- typically limited to 6-mers -- seems to be inadequate. One reason is the rapid formation of diketopiperazines (DKPs) from dipeptides. In this study, using a hydrothermal microflow reactor, we show that the one-step synthesis of oligopeptide-like molecules of length up to 20-mers proceeds from Glu and Asp. Yields of up to 0.17-0.57% were obtained in an acidic solution within 183 s at 250-310 degrees C, as evaluated by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) analysis and different types of high-performance liquid chromatography (HPLC) analyses. The present study indicates that Glu and Asp may have played important roles in the chemical evolution of oligopeptide-like molecules in hydrothermal vent environments on primitive earth.
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