ArticlePloS one2008
Fine mapping of posttranslational modifications of the linker histone H1 from Drosophila melanogaster.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Histone H1 Post-Translational Modifications: Update and Future Perspectives.International journal of molecular sciences · 2020Review
- Dependence of Chromatosome Structure on Linker Histone Sequence and Posttranslational Modification.Biophysical journal · 2018Article
- Article
- The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle.EMBO reports · 2015Review
- A novel approach for studying histone H1 function in vivo.Genetics · 2015Article
- Quantitative proteomic analysis of histone modifications.Chemical reviews · 2015Review
- The extended AT-hook is a novel RNA binding motif.RNA biology · 2015Article
- Allelic isoforms of the chicken and duck histone H1.a.Cellular & molecular biology letters · 2014Article
- Article
- Mass spectrometry-based proteomics for the analysis of chromatin structure and dynamics.International journal of molecular sciences · 2013Article
- Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster.Nucleic acids research · 2012Article
- Global analysis of the relationship between JIL-1 kinase and transcription.PLoS genetics · 2011Article
- Assaying pharmacodynamic endpoints with targeted therapy: flavopiridol and 17AAG induced dephosphorylation of histone H1.5 in acute myeloid leukemia.Proteomics · 2010Article
- Onset of grain filling is associated with a change in properties of linker histone variants in maize kernels.Planta · 2010Article
- Drosophila ISWI regulates the association of histone H1 with interphase chromosomes in vivo.Genetics · 2009Article
- Role of chromatin states in transcriptional memory.Biochimica et biophysica acta · 2009Review
- Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The linker histone H1 binds to the DNA in between adjacent nucleosomes and contributes to chromatin organization and transcriptional control. It is known that H1 carries diverse posttranslational modifications (PTMs), including phosphorylation, lysine methylation and ADP-ribosylation. Their biological functions, however, remain largely unclear. This is in part due to the fact that most of the studies have been performed in organisms that have several H1 variants, which complicates the analyses. We have chosen Drosophila melanogaster, a model organism, which has a single H1 variant, to approach the study of the role of H1 PTMs during embryonic development. Mass spectrometry mapping of the entire sequence of the protein showed phosphorylation only in the ten N-terminal amino acids, mostly at S10. For the first time, changes in the PTMs of a linker H1 during the development of a multicellular organism are reported. The abundance of H1 monophosphorylated at S10 decreases as the embryos age, which suggests that this PTM is related to cell cycle progression and/or cell differentiation. Additionally, we have found a polymorphism in the protein sequence that can be mistaken with lysine methylation if the analysis is not rigorous.
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