ArticleJournal of cell science2008
Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd.
Article in Journal of cell science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Chromosomal Rearrangements and Altered Nuclear Organization: Recent Mechanistic Models in Cancer.Cancers · 2021Review
- Article
- Article
- Towards quantitative analysis of gene regulation by enhancers.Epigenomics · 2017Review
- Tissue-specific NETs alter genome organization and regulation even in a heterologous system.Nucleus (Austin, Tex.) · 2017Article
- Anchoring a Leviathan: How the Nuclear Membrane Tethers the Genome.Frontiers in genetics · 2016Review
- CTCF controls HOXA cluster silencing and mediates PRC2-repressive higher-order chromatin structure in NT2/D1 cells.Molecular and cellular biology · 2014Article
- Evolutionary constraints favor a biophysical model explaining hox gene collinearity.Current genomics · 2013Article
- FGF signalling regulates chromatin organisation during neural differentiation via mechanisms that can be uncoupled from transcription.PLoS genetics · 2013Article
- Distant activation of transcription: mechanisms of enhancer action.Molecular and cellular biology · 2012Review
- Navigating the epigenetic landscape of pluripotent stem cells.Nature reviews. Molecular cell biology · 2012Review
- Comparison of models for the collinearity of hox genes in the developmental axes of vertebrates.Current genomics · 2012Article
- The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA.Genes & development · 2011Article
- Advancing our understanding of functional genome organisation through studies in the fission yeast.Current genetics · 2011Review
- Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.Molecular cell · 2010Article
- Lack of bystander activation shows that localization exterior to chromosome territories is not sufficient to up-regulate gene expression.Genome research · 2009Article
- A biophysical mechanism may control the collinearity of Hoxd genes during the early phase of limb development.Human genomics · 2009Article
- Reorganization of chromatin is an early response to nitrogen starvation in Schizosaccharomyces pombe.Chromosoma · 2009Article
- Establishment of Hox vertebral identities in the embryonic spine precursors.Current topics in developmental biology · 2009Review
- Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.The Journal of cell biology · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The extent to which the nuclear organisation of a gene impacts on its ability to be expressed, or whether nuclear organisation merely reflects gene expression states, remains an important but unresolved issue. A model system that has been instrumental in investigating this question utilises the murine Hox gene clusters encoding homeobox-containing proteins. Nuclear reorganisation and chromatin decondensation, initiated towards the 3' end of the clusters, accompanies activation of Hox genes in both differentiation and development, and might be linked to mechanisms underlying colinearity. To investigate this, and to delineate the cis-acting elements involved, here we analyse the nuclear behaviour of a 3' Hoxb1 transgene transposed to the 5' end of the Hoxd cluster. We show that this transgene contains the cis-acting elements sufficient to initiate ectopic local nuclear reorganisation and chromatin decondensation and to break Hoxd colinearity in the primitive streak region of the early embryo. Significantly, in rhombomere 4, the transgene is able to induce attenuated nuclear reorganisation and decondensation of Hoxd even though there is no detectable expression of the transgene at this site. This shows that reorganisation of chromosome territories and chromatin decondensation can be uncoupled from transcription itself and suggests that they can therefore operate upstream of gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.