ArticleInsect biochemistry and molecular biology2008
Annotation and expression profiling of apoptosis-related genes in the yellow fever mosquito, Aedes aegypti.
Article in Insect biochemistry and molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 65 citations in OpenAlex.
- A broad-spectrum Chromobacterium biolarvicide formulation disrupts mosquito development through gut damage and apoptotic cell death and compromises vector competence.Communications biology · 2026Article
- Evolution and assembly ofOpen biology · 2023Article
- Factors Affecting Arbovirus Midgut Escape in Mosquitoes.Pathogens (Basel, Switzerland) · 2023Review
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- Defining the mechanisms of action and mosquito larva midgut response to a yeast-encapsulated orange oil larvicide.Parasites & vectors · 2022Article
- Evolutionary novelty in the apoptotic pathway of aphids.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Temperature Dramatically Shapes Mosquito Gene Expression With Consequences for Mosquito-Zika Virus Interactions.Frontiers in microbiology · 2020Article
- Pectin Digestion in Herbivorous Beetles: Impact of Pseudoenzymes Exceeds That of Their Active Counterparts.Frontiers in physiology · 2019Article
- Mosquito Innate Immunity.Insects · 2018Review
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- Infection pattern and transmission potential of chikungunya virus in two New World laboratory-adapted Aedes aegypti strains.Scientific reports · 2016Article
- The Strica Homolog AaCASPS16 Is Involved in Apoptosis in the Yellow Fever Vector, Aedes albopictus.PloS one · 2016Article
- Rice ragged stunt virus-induced apoptosis affects virus transmission from its insect vector, the brown planthopper to the rice plant.Scientific reports · 2015Article
- Rapid selection against arbovirus-induced apoptosis during infection of a mosquito vector.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Novel Genetic and Molecular Tools for the Investigation and Control of Dengue Virus Transmission by Mosquitoes.Current tropical medicine reports · 2014Article
- Article
- In silico models for predicting vector control chemicals targeting Aedes aegypti.SAR and QSAR in environmental research · 2014Review
- Article
- Effects of manipulating apoptosis on Sindbis virus infection of Aedes aegypti mosquitoes.Journal of virology · 2012Article
- Global cross-talk of genes of the mosquito Aedes aegypti in response to dengue virus infection.PLoS neglected tropical diseases · 2011Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Apoptosis has been extensively studied in Drosophila by both biochemical and genetic approaches, but there is a lack of knowledge about the mechanisms of apoptosis regulation in other insects. In mosquitoes, apoptosis occurs during Plasmodium and arbovirus infection in the midgut, suggesting that apoptosis plays a role in mosquito innate immunity. We searched the Aedes aegypti genome for apoptosis-related genes using Drosophila and Anopheles gambiae protein sequences as queries. In this study we have identified eleven caspases, three inhibitor of apoptosis (IAP) proteins, a previously unreported IAP antagonist, and orthologs of Drosophila Ark, Dnr1, and BG4 (also called dFadd). While most of these genes have been previously annotated, we have improved the annotation of several of them, and we also report the discovery of four previously unannotated apoptosis-related genes. We examined the developmental expression profile of these genes in Ae. aegypti larvae, pupae and adults, and we also studied the function of a novel IAP antagonist, IMP. Expression of IMP in mosquito cells caused apoptosis, indicating that it is a functional pro-death protein. Further characterization of these genes will help elucidate the molecular mechanisms of apoptosis regulation in Ae. aegypti.
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