Trial reportThe British journal of general practice : the journal of the Royal College of General Practitioners2007
Does eating yogurt prevent antibiotic-associated diarrhoea? A placebo-controlled randomised controlled trial in general practice.
Trial report in The British journal of general practice : the journal of the Royal College of General Practitioners, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Yogurt, cultured fermented milk, and health: a systematic review.Nutrition reviews · 2021Pooled it
- Probiotics for the prevention of pediatric antibiotic-associated diarrhea.The Cochrane database of systematic reviews · 2019Pooled it
- Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children.The Cochrane database of systematic reviews · 2017Pooled it
- Systematic review and meta-analysis of Saccharomyces boulardii in adult patients.World journal of gastroenterology · 2010Pooled it
- Putative Probiotic Strains Isolated from Kefir Improve Gastrointestinal Health Parameters in Adults: a Randomized, Single-Blind, Placebo-Controlled Study.Probiotics and antimicrobial proteins · 2020Trial
- Can probiotic yogurt prevent diarrhoea in children on antibiotics? A double-blind, randomised, placebo-controlled study.BMJ open · 2015Trial
- Clinical efficacy comparison of Saccharomyces boulardii and yogurt fluid in acute non-bloody diarrhea in children: a randomized, controlled, open label study.The American journal of tropical medicine and hygiene · 2010Trial
- Natural Bioactive Compounds Enriched Functional Yogurt: Impact on the Probiotic Bacteria and Its Potential Health Benefits.Probiotics and antimicrobial proteins · 2026Review
- Malnutrition and Its Influence on Gut sIgA-Microbiota Dynamics.Biomedicines · 2025Review
- Role of Probiotics in Human Health.Cureus · 2022Review
- Beneficial Effects of Yoghurts and Probiotic Fermented Milks and Their Functional Food Potential.Foods (Basel, Switzerland) · 2022Review
- State-of-the-Art of the Nutritional Alternatives to the Use of Antibiotics in Humans and Monogastric Animals.Animals : an open access journal from MDPI · 2020Review
- Article
- Infant dietary intake of yogurt and cheese and gastroenteritis at 1 year of age: The Japan Environment and Children's Study.PloS one · 2019Article
- A Review on Gut Remediation of Selected Environmental Contaminants: Possible Roles of Probiotics and Gut Microbiota.Nutrients · 2018Review
- Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients-A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2017Review
- The scale of the evidence base on the health effects of conventional yogurt consumption: findings of a scoping review.Frontiers in pharmacology · 2015Article
- Probiotics in the prevention of antibiotic-associated diarrhoea and Clostridium difficile infection.Therapeutic advances in gastroenterology · 2011Article
- Antibiotic-associated diarrhoea.The British journal of general practice : the journal of the Royal College of General Practitioners · 2008Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProbiotic capsules have been shown to reduce the incidence of antibiotic-associated diarrhoea in a number of settings. If probiotic yogurt were equally efficacious then it would provide a simple and cost-effective means of preventing antibiotic-associated diarrhoea.
aimTo investigate whether eating live bio yogurt at the time of taking oral antibiotics can prevent antibiotic-associated diarrhoea. DESIGN OF STUDY: This study was a three-arm (bio yogurt, commercial yogurt, no yogurt) randomised controlled trial with double blinding between the two yogurt arms.
settingA single primary care general practice surgery in Hingham, Norfolk. The study population included all ages except babies.
methodPatients aged over 1 year who required a 1-week course of antibiotics were included in the study. There was complete follow up for 369 patients. The intervention was the consumption of 150 ml of live strawberry-flavoured yogurt for 12 days, starting on the first day of taking the antibiotic. Diarrhoea was defined as 'three or more loose stools per day over at least 2 consecutive days' within 12 days of starting the antibiotics.
resultsOf the 120 patients in the no-yogurt group, 17 (14%, 95% confidence interval [CI] = 9.0 to 21.5) developed diarrhoea. Of the 118 given commercial yogurt, 13 (11%, 95% CI = 6.6 to 17.9) developed diarrhoea; nine of the 131 patients (7%; 95% CI = 3.7 to 12.5) given bio yogurt developed diarrhoea (P = 0.17).
conclusionOverall, this study failed to demonstrate that yogurt has any effect on antibiotic-associated diarrhoea.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.