ArticleArthritis research & therapy2008
Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis.
Article in Arthritis research & therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- Phytochemistry and Pharmacological Activity ofCombinatorial chemistry & high throughput screening · 2024Review
- Metabolomics-Based Analysis of the Effects of Different Cultivation Strategies on Metabolites ofMetabolites · 2023Article
- Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2022Review
- The Bioflavonoids Rutin and Rutin Succinate Neutralize the Toxins ofFrontiers in pharmacology · 2022Article
- Development of biodegradable zein-based bilayer coatings for drug-eluting stents.RSC advances · 2021Article
- Lipoxin A4-Mediated p38 MAPK Signaling Pathway Protects Mice Against Collagen-Induced Arthritis.Biochemical genetics · 2021Article
- Rutin (quercetin-3-rutinoside) modulates the hemostatic disturbances and redox imbalance induced by Bothrops jararaca snake venom in mice.PLoS neglected tropical diseases · 2018Article
- Pathophysiological Mechanisms of Chronic Venous Disease and Implications for Venoactive Drug Therapy.International journal of molecular sciences · 2018Review
- Efficacy of Bromelain along with Trypsin, Rutoside Trihydrate Enzymes and Diclofenac Sodium Combination Therapy for the treatment of TMJ Osteoarthritis - A Randomised Clinical Trial.Journal of clinical and diagnostic research : JCDR · 2017Article
- Treatment with Rutin - A Therapeutic Strategy for Neutrophil-Mediated Inflammatory and Autoimmune Diseases: - Anti-inflammatory Effects of Rutin on Neutrophils.Journal of pharmacopuncture · 2017Article
- Protective effect of Malva sylvestris L. extract in ischemia-reperfusion induced acute kidney and remote liver injury.PloS one · 2017Article
- Rutin Attenuates Hepatotoxicity in High-Cholesterol-Diet-Fed Rats.Oxidative medicine and cellular longevity · 2016Article
- Metabolic and Molecular Changes of the Phenylpropanoid Pathway in Tomato (Frontiers in plant science · 2016Article
- Article
- Bioactive Compound Content and Cytotoxic Effect on Human Cancer Cells of Fresh and Processed Yellow Tomatoes.Molecules (Basel, Switzerland) · 2015Article
- Enhancing the health-promoting effects of tomato fruit for biofortified food.Mediators of inflammation · 2014Review
- Role of rutin on nitric oxide synthesis in human umbilical vein endothelial cells.TheScientificWorldJournal · 2014Article
- Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat.BMC complementary and alternative medicine · 2013Article
- Antirheumatoid Arthritis Activities and Chemical Compositions of Phenolic Compounds-Rich Fraction from Urtica atrichocaulis, an Endemic Plant to China.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Anti-arthritic Effects of Total Flavonoids from Juniperus sabina on Complete Freund's Adjuvant Induced Arthritis in Rats.Pharmacognosy magazineArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDietary flavonols may play an important role in the adjunct therapy of chronic inflammation. The availability of therapeutic formulations of pentahydroxyflavone glycoside, rutoside (RU), led us to investigate the ability of this molecule to modulate the release of various proinflammatory mediators from human activated macrophages in vitro and to ameliorate arthritic markers in a rat model.
methodsRU was added simultaneously to human macrophages during their activation. Cells were then analyzed for inflammation-related gene expression using a specific array, and cell supernatants were collected to measure inflammatory mediators. RU was also injected into adjuvant-induced arthritic rats, and disease progression and body weight were evaluated until 50 days after injection. Sera and peritoneal macrophages were also collected to quantify the RU effect on various inflammatory markers.
resultsRU inhibited inflammation-related gene expression in activated human macrophages and the release of nitric oxide, tumor necrosis factor-alpha, interleukin (IL)-1, and IL-6 from these cells. In a rat model, RU inhibited clinical signs of chronic arthritis, correlating with decreased levels of inflammatory cytokines detected in rat sera and macrophage supernatants.
conclusionThus, RU may have clinical value in reducing inflammatory manifestations in human arthritis and other inflammatory diseases.
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