Trial reportBritish journal of clinical pharmacology2008
Effect of homeopathy on analgesic intake following knee ligament reconstruction: a phase III monocentre randomized placebo controlled study.
Trial report in British journal of clinical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05283434 (Arnica and the Management of Pain in Acute Musculoskeletal Extremity Injuries), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Arnica and the Management of Pain in Acute Musculoskeletal Extremity Injuries
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Assessing the magnitude of reporting bias in trials of homeopathy: a cross-sectional study and meta-analysis.BMJ evidence-based medicine · 2022Pooled it
- No effect of a homoeopathic combination of Arnica montana and Bryonia alba on bleeding, inflammation, and ischaemia after aortic valve surgery.British journal of clinical pharmacology · 2010Trial
- A Systematic Review of Arnica montana in Postoperative Recovery Across Surgical Specialties.Cureus · 2026Review
- Effects ofPlants (Basel, Switzerland) · 2024Review
- [Recommendations of the committee on complementary medicine and nutrition in ayurvedic medicine, homeopathy, nutrition and Mediterranean diet].Zeitschrift fur Rheumatologie · 2023Review
- Against all odds-the persistent popularity of homeopathy.Wiener klinische Wochenschrift · 2020Review
- Article
- Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens.BMC complementary and alternative medicine · 2014Article
- Supported by science?: what canadian naturopaths advertise to the public.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2011Article
- Novel wound healing powder formulation for the treatment of venous leg ulcers.The journal of the American College of Certified Wound Specialists · 2011Article
- Use of homeopathy in pediatric oncology in Germany.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- The truth about homeopathy.British journal of clinical pharmacology · 2008Review
- Sensitivity: real (interferons, odorants) and imagined (homeopathy).British journal of clinical pharmacology · 2008Article
- Is there a role for homeopathy in breast cancer surgery? A first randomized clinical trial on treatment withJournal of intercultural ethnopharmacologyArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
what is already known about this subjectThe efficacy of homeopathy is still under debate and a recent meta-analysis recommended further randomized double-blind clinical trials to identify any clinical situation in which homeopathy might be effective. WHAT THIS STUDY ADDS: The complex of homeopathy tested in this study (Arnica montana 5 CH, Bryonia alba 5 CH, Hypericum perforatum 5 CH and Ruta graveolens 3 DH) is not superior to placebo in reducing 24 h morphine consumption after knee ligament reconstruction.
aimsThe efficacy of homeopathy is still under debate. The objective of this study was to assess the efficacy of homeopathic treatment (Arnica montana 5 CH, Bryonia alba 5 CH, Hypericum perforatum 5 CH and Ruta graveolens 3 DH) on cumulated morphine intake delivered by PCA over 24 h after knee ligament reconstruction.
methodsThis was an add-on randomized controlled study with three parallel groups: a double-blind homeopathic or placebo arm and an open-label noninterventional control arm. Eligible patients were 18-60 years old candidates for surgery of the anterior cruciate ligament. Treatment was administered the evening before surgery and continued for 3 days. The primary end-point was cumulated morphine intake delivered by PCA during the first 24 h inferior or superior/equal to 10 mg day(-1).
resultsOne hundred and fifty-eight patients were randomized (66 in the placebo arm, 67 in the homeopathic arm and 25 in the noninterventional group). There was no difference between the treated and the placebo group for primary end-point (mean (95% CI) 48% (35.8, 56.3), and 56% (43.7, 68.3), required less than 10 mg day(-1) of morphine in each group, respectively). The homeopathy treatment had no effect on morphine intake between 24 and 72 h or on the visual analogue pain scale, or on quality of life assessed by the SF-36 questionnaire. In addition, these parameters were not different in patients enrolled in the open-label noninterventional control arm.
conclusionsThe complex of homeopathy tested in this study was not superior to placebo in reducing 24 h morphine consumption after knee ligament reconstruction.
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