ReviewExpert review of vaccines2008
Analysis of epitope information related to Bacillus anthracis and Clostridium botulinum.
Review in Expert review of vaccines, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A meta-analysis of the existing knowledge of immunoreactivity against hepatitis C virus (HCV).PloS one · 2012Pooled it
- Meta-analysis of all immune epitope data in the Flavivirus genus: inventory of current immune epitope data status in the context of virus immunity and immunopathology.Viral immunology · 2010Pooled it
- Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues.Parasite immunology · 2009Pooled it
- Immunologic and Protective Properties of Subunit- vs. Whole Toxoid-Derived Anti-Botulinum Equine Antitoxin.Vaccines · 2022Article
- Article
- Characterization and immunological activity of different forms of recombinant secreted Hc of botulinum neurotoxin serotype B products expressed in yeast.Scientific reports · 2015Article
- Production and evaluation of a recombinant subunit vaccine against botulinum neurotoxin serotype B using a 293E expression system.Human vaccines & immunotherapeutics · 2015Article
- Prediction of epitope-based peptides for the utility of vaccine development from fusion and glycoprotein of nipah virus using in silico approach.Advances in bioinformatics · 2014Article
- A novel mechanism for antibody-based anthrax toxin neutralization: inhibition of prepore-to-pore conversion.The Journal of biological chemistry · 2012Article
- T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- A comparison of epitope repertoires associated with myasthenia gravis in humans and nonhuman hosts.Autoimmune diseases · 2012Article
- Purification, modeling, and analysis of botulinum neurotoxin subtype A5 (BoNT/A5) from Clostridium botulinum strain A661222.Applied and environmental microbiology · 2011Article
- Recent advances in B-cell epitope prediction methods.Immunome research · 2010Article
- NIAID workshop on Flavivirus immunity.Viral immunology · 2010Article
- Efficacy of a potential trivalent vaccine based on Hc fragments of botulinum toxins A, B, and E produced in a cell-free expression system.Clinical and vaccine immunology : CVI · 2010Article
- Design and utilization of epitope-based databases and predictive tools.Immunogenetics · 2010Review
- Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.Future microbiology · 2010Review
- Neutralizing monoclonal antibodies directed against defined linear epitopes on domain 4 of anthrax protective antigen.Infection and immunity · 2009Article
- Immunogenicity of Bacillus anthracis protective antigen domains and efficacy of elicited antibody responses depend on host genetic background.Clinical and vaccine immunology : CVI · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
We have reviewed the information about epitopes of immunological interest from Clostridium botulinum and Bacillus anthracis, by mining the Immune Epitope Database and Analysis Resource. For both pathogens, the vast majority of epitopes reported to date are derived from a single protein: the protective antigen of B. anthracis and the neurotoxin type A of C. botulinum. A detailed analysis of the data was performed to characterize the function, localization and conservancy of epitopes identified as neutralizing and/or protective. In order to broaden the scope of this analysis, we have also included data describing immune responses against defined fragments (over 50 amino acids long) of the relevant antigens. The scarce information on T-cell determinants and on epitopes from other antigens besides the toxins, highlights a gap in our knowledge and identifies areas for future research. Despite this, several distinct structures at the epitope and fragment level are described herein, which could be potential additions to future vaccines or targets of novel immunotherapeutics and diagnostic reagents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.