ArticleDiabetologia2008
Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans.
Article in Diabetologia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- TUB gene expression in hypothalamus and adipose tissue and its association with obesity in humans.International journal of obesity (2005) · 2018Pooled it
- FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial.Diabetes · 2012Trial
- Beyond theChildren (Basel, Switzerland) · 2026Article
- FTO in cardiovascular diseases: mechanisms, context dependence, and translational opportunities.Frontiers in cell and developmental biology · 2026Review
- An obesogenic FTO allele causes accelerated development, growth and insulin resistance in human skeletal muscle cells.Nature communications · 2025Article
- Association between Fat Mass and Obesity-Related Transcript Polymorphisms and Osteoporosis Phenotypes.Journal of bone metabolism · 2024Article
- Epitranscriptomics in metabolic disease.Nature metabolism · 2023Review
- The importance of considering regulatory domains in genome-wide analyses - the nearest gene is often wrong!Biology open · 2022Review
- Epigenetic regulation of energy metabolism in obesity.Journal of molecular cell biology · 2021Review
- Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation.Nature immunology · 2021Article
- m6A Regulators in Human Adipose Tissue - Depot-Specificity and Correlation With Obesity.Frontiers in endocrinology · 2021Article
- Correlations between FTO Gene Polymorphisms and TSH Level in Uyghur Chinese Patients with Type 2 Diabetes.BioMed research international · 2021Article
- Up-regulation of FTO gene expression was associated with increase in skeletal muscle mass in overweight male adolescents.Archives of medical science : AMS · 2019Article
- RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases.Frontiers in cardiovascular medicine · 2019Review
- FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications.Journal of lipid research · 2018Article
- Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population.BMC medical genetics · 2017Article
- Article
- Association of polymorphic markers of genesPeerJ · 2017Article
- Expression of candidate genes associated with obesity in peripheral white blood cells of Mexican children.Archives of medical science : AMS · 2016Article
- Is fat mass & obesity-associated (FTO) gene master regulator of obesity ?The Indian journal of medical research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisRecently, FTO was identified as a candidate gene contributing to both childhood and severe adult obesity. We tested the hypothesis that mRNA expression of FTO and/or of the neighbouring RPGRIP1L in adipose tissue correlates with measures of obesity and fat distribution. We also investigated whether the FTO obesity risk alleles might explain variability in FTO and RPGRIP1L mRNA expression.
methodsIn paired samples of visceral and subcutaneous adipose tissue from 55 lean and obese participants, we investigated whether FTO and RPGRIP1L mRNA expression is fat depot-specific, altered in obesity and related to measures of fat accumulation, insulin sensitivity and glucose metabolism. All participants were genotyped for the obesity-associated rs8050136 FTO variant.
resultsFTO mRNA expression was threefold higher in subcutaneous than in visceral adipose tissue. Subcutaneous FTO expression correlated with visceral FTO expression. FTO gene expression in both depots correlated with age and was negatively correlated to BMI and per cent body fat. FTO mRNA levels were not related to measures of insulin sensitivity and glucose metabolism. RPGRIP1L mRNA expression was 1.6-fold higher in visceral than in subcutaneous adipose tissue, but did not correlate with anthropometric and metabolic characteristics. There was no association between rs8050136 and FTO or RPGRIP1L mRNA expression in adipose tissue. CONCLUSIONS/
interpretationExpression of adipose tissue FTO mRNA is fat depot-specific and negatively correlates with measures of obesity. However, the direction of this relationship still needs to be elucidated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.