ArticleJournal of neural transmission (Vienna, Austria : 1996)2008
A functional polymorphism of the micro-opioid receptor gene is associated with completed suicides.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Polymorphism A118G of opioid receptor mu 1 (OPRM1) is associated with emergence of suicidal ideation at antidepressant onset in a large naturalistic cohort of depressed outpatients.Scientific reports · 2019Trial
- Molecular genetic basis of the primary emotions in young adults: an exploratory analysis of genetic polymorphisms across dopamine, serotonin, oxytocin, endogenous opioid, and neurotrophic factor pathways.Frontiers in pharmacology · 2025Article
- Associations of the A118G OPRM1 polymorphism with sociotropy and interpersonal sensitivity.Brain and behavior · 2022Article
- Association Between the A118G Polymorphism of theNeuropsychiatric disease and treatment · 2021Article
- Roles of β-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism.International journal of molecular sciences · 2020Review
- The Role of Opiates in Social Pain and Suicidal Behavior.Current topics in behavioral neurosciences · 2020Review
- Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach.Molecular psychiatry · 2015Article
- An overview of the neurobiology of suicidal behaviors as one meta-system.Molecular psychiatry · 2015Review
- Toward a biosignature for suicide.The American journal of psychiatry · 2014Review
- Opioid receptor polymorphism A118G associated with clinical severity in a drug overdose population.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2013Article
- Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons.Anesthesiology · 2011Article
- Neurotransmitter and neuromodulator genes associated with a history of depressive symptoms in individuals with alcohol dependence.Alcoholism, clinical and experimental research · 2011Article
- OPRM1 gene variants modulate amphetamine-induced euphoria in humans.Genes, brain, and behavior · 2011Article
- Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients.Archives of general psychiatry · 2010Article
- No genetic association between A118G polymorphism of μ-opioid receptor gene and schizophrenia and bipolar disorders.Indian journal of psychiatryArticle
- Variation in OPRM1 and risk of suicidal behavior in drug-dependent individuals.The American journal on addictionsArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recent linkage study suggested that a putative locus for suicidal behavior independent of psychiatric disease phenotypes lies at 5' upstream of the micro-opioid receptor (OPRM1) gene. We explored an association between suicide and genetic variations of the OPRM1 using a case-control study of 183 completed suicides and 374 control subjects. We genotyped four single nucleotide polymorphisms (SNPs) including a common A118G SNP. The genotypic and allelic distributions of the A118G SNP were significantly different between the completed suicide and control groups (P = 0.014 and 0.039, respectively). A dominant model analysis of the A118G SNP showed an enhanced association with suicide (P = 0.0041, Odds ratio 0.575) and this significant association was observed with a logistic regression analysis that takes sex and age factors into account (P = 0.021). Our results raise the possibility that the A118G SNP of the OPRM1 gene is associated with suicide.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.