Evidence map›Paper›PMID 18250365›Full record

Trial reportHypertension (Dallas, Tex. : 1979)2008

Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.

Andrew J Webb, Nakul Patel, Stavros Loukogeorgakis, Mike Okorie, Zainab Aboud, Shivani Misra, Rahim Rashid, Philip Miall, John Deanfield, Nigel Benjamin and 3 more

4 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hypertension (Dallas, Tex. : 1979), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 399 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
399citing papers in PubMed, 11 pooled it
24.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01236872 nacompletednot on this mapstarted 2009, after this paper: background citation

The Acute Effect of Beetroot Juice on Circulating Nitrate and Nitrite Levels and Blood Pressure in Normotensives and Hypertensives

TypeinterventionalSponsorQueen Mary University of LondonRan2009 to 2010Enrolled15ConditionsHypertensionArmsBeetroot juice, Water
NCT01384968 nacompletednot on this mapstarted 2011, after this paper: background citation

Acute Dietary Nitrate Supplementation to Improve Performance in Endurance Trained Athletes

TypeinterventionalSponsorMaastricht University Medical CenterRan2011 to 2012Enrolled20ConditionsAcute Nitrate Ingestion on Athletic PerformanceArmsbeetroot juice
NCT03506646 nacompletednot on this mapstarted 2018, after this paper: background citation

Dietary Nitrate Supplementation and Thermoregulation During Exercise

TypeinterventionalSponsorUniversity of NebraskaRan2018 to 2022Enrolled11ConditionsPeripheral Arterial Disease, Peripheral Artery DiseaseArmsPlacebo, Beet root juice
NCT06375694 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Oral Probiotic Effect on Dietary Nitrate to Plasma Nitrite Production

TypeinterventionalSponsorWake Forest UniversityRan2024 to 2025Enrolled20ConditionsHypertension, Cardiovascular Diseases, DiabetesArmsHerbiotics Oral + Ent Probiotic, Placebo
3 · Its place in the literature

Who cites it

399 citing papers in PubMed, 11 syntheses or guidelines pooled it, 1,064 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

339 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Andrew J WebbClinical Pharmacology, William Harvey Research Institute, Barts & the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Nakul Patel
Stavros Loukogeorgakis
Mike Okorie
Zainab Aboud
Shivani Misra
Rahim Rashid
Philip Miall
John Deanfield
Nigel Benjamin
Raymond MacAllister
Adrian J Hobbs
Amrita Ahluwalia
Queen Mary University of London · GB

Funding

Wellcome Trust 067422
6 · The paper itself

Abstract

Diets rich in fruits and vegetables reduce blood pressure (BP) and the risk of adverse cardiovascular events. However, the mechanisms of this effect have not been elucidated. Certain vegetables possess a high nitrate content, and we hypothesized that this might represent a source of vasoprotective nitric oxide via bioactivation. In healthy volunteers, approximately 3 hours after ingestion of a dietary nitrate load (beetroot juice 500 mL), BP was substantially reduced (Delta(max) -10.4/8 mm Hg); an effect that correlated with peak increases in plasma nitrite concentration. The dietary nitrate load also prevented endothelial dysfunction induced by an acute ischemic insult in the human forearm and significantly attenuated ex vivo platelet aggregation in response to collagen and ADP. Interruption of the enterosalivary conversion of nitrate to nitrite (facilitated by bacterial anaerobes situated on the surface of the tongue) prevented the rise in plasma nitrite, blocked the decrease in BP, and abolished the inhibitory effects on platelet aggregation, confirming that these vasoprotective effects were attributable to the activity of nitrite converted from the ingested nitrate. These findings suggest that dietary nitrate underlies the beneficial effects of a vegetable-rich diet and highlights the potential of a "natural" low cost approach for the treatment of cardiovascular disease.

Indexed as

Beta vulgarisDietAdolescentAdultBlood PressureCross-Over StudiesEndothelium, VascularHumansHypertensionMiddle AgedNitratesNitritesPlatelet AggregationReperfusion InjurySalivaTongueNitratesNitrites

Identifiers

PMID18250365
PMCPMC2839282
OpenAlexW2161221966

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.