ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2008
Relative weight at age 12 and risk of postmenopausal breast cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Modifiable risk factors in women at high risk of breast cancer: a systematic review.Breast cancer research : BCR · 2023Pooled it
- Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Trial
- Early life body size and puberty markers as predictors of breast cancer risk later in life: A neural network analysis.PloS one · 2024Article
- Childhood adiposity, serum metabolites and breast density in young women.Breast cancer research : BCR · 2022Article
- Birthweight, childhood body size, and timing of puberty and risks of breast cancer by menopausal status and tumor receptor subtypes.Breast cancer research : BCR · 2022Article
- Article
- Early-Life Body Adiposity and the Breast Tumor Transcriptome.Journal of the National Cancer Institute · 2021Article
- Body size and weight change over adulthood and risk of breast cancer by menopausal and hormone receptor status: a pooled analysis of 20 prospective cohort studies.European journal of epidemiology · 2021Article
- Age-specific breast cancer risk by body mass index and familial risk: prospective family study cohort (ProF-SC).Breast cancer research : BCR · 2018Article
- Breast cancer risk prediction: an update to the Rosner-Colditz breast cancer incidence model.Breast cancer research and treatment · 2017Article
- The Premenopausal Breast Cancer Collaboration: A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Review
- Age at Menarche and Late Adolescent Adiposity Associated with Mammographic Density on Processed Digital Mammograms in 24,840 Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Body size in early life and risk of breast cancer.Breast cancer research : BCR · 2017Article
- Height and Body Size in Childhood, Adolescence, and Young Adulthood and Breast Cancer Risk According to Molecular Subtype in the Nurses' Health Studies.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- Body fatness throughout the life course and the incidence of premenopausal breast cancer.International journal of epidemiology · 2016Article
- Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent.PLoS medicine · 2016Article
- Trajectory of body shape across the lifespan and cancer risk.International journal of cancer · 2016Article
- Body fatness during childhood and adolescence and breast density in young women: a prospective analysis.Breast cancer research : BCR · 2015Article
- Body size throughout adult life influences postmenopausal breast cancer risk among hispanic women: the breast cancer health disparities study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- Body size in early life and breast cancer risk in African American and European American women.Cancer causes & control : CCC · 2013Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEarly adolescent weight may affect the risk of postmenopausal breast cancer, and this association may be modified by a family history of breast or ovarian cancer in a first-degree relative, and/or estrogen (ER) and progesterone (PR) receptor status of the disease.
methodsRelative weight at age 12 years (above, below, or average weight compared with peers) and family history were ascertained using a mailed questionnaire in 1986, in the Iowa Women's Health Study, a prospective cohort study of postmenopausal women. Incident breast cancer cases (including ER and PR status) were identified using the Iowa Surveillance, Epidemiology, and End Results Cancer Registry. Relative risks (RR) and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards regression, and were adjusted for breast cancer risk factors, including body mass index at age 18 years and body mass index at study baseline.
resultsThrough 2003, 2,503 cases of postmenopausal breast cancer were identified among 35,941 women in the analytic cohort. Compared with women with average weight at age 12 years, there was no association of below average weight with risk of breast cancer (RR, 1.02; 95% CI, 0.92-1.13), whereas women with above average weight had a lower risk (RR, 0.85; 95% CI, 0.74-0.98). There was no evidence of an interaction between weight at age 12 years and family history (P = 0.44). The inverse association of above average weight with risk of breast cancer was strongest for PR- tumors (RR, 0.62; 95% CI, 0.43-0.89), intermediate for ER+ (RR, 0.80; 95% CI, 0.67-0.96) and ER- (RR, 0.77; 95% CI, 0.50-1.19) tumors, and weakest for PR+ tumors (RR, 0.90; 95% CI, 0.74-1.09). These associations were not modified by a family history (all P > 0.18). In a joint ER/PR analyses, the strongest inverse association with above average weight at age 12 years was seen for ER+/PR- (RR, 0.49; 95% CI, 0.29-0.85).
conclusionAbove average weight at age 12 years was inversely associated with risk of postmenopausal breast cancer, and was not modified by a family history of the disease. The inverse association was strongest for ER+/PR- tumors.
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