ArticleProceedings of the National Academy of Sciences of the United States of America2008
Evolution of polyketide synthases in bacteria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 189 citations in OpenAlex.
- Genomic and Functional Characterization of Bacillus subtilis Strain 55-7 as a Dual-Function Bioinoculant for Fungal Biocontrol and Enhancing Sweet Corn Seedling Growth Under Reduced Fertilizer Input.Applied biochemistry and biotechnology · 2026Article
- The evolutionary processes of bacterial aromatic polyketide ketosynthases.Genome biology · 2026Article
- Skeletal editing via multi-step engineering of a modular polyketide synthase.Nature communications · 2026Article
- A comprehensive analysis of human gut microbial biosynthesis gene clusters unveiling the dominant role ofmSystems · 2025Article
- Antibacterial Compounds Isolated from Endophytic Fungi Reported from 2021 to 2024.Antibiotics (Basel, Switzerland) · 2025Review
- Strategic Acyl Carrier Protein Engineering Enables Functional Type II Polyketide Synthase Reconstitution In Vitro.ACS chemical biology · 2025Article
- Comparative Genomics and Biosynthetic Cluster Analysis of Antifungal Secondary Metabolites of Three Strains ofMicroorganisms · 2024Article
- Analysis of the Setomimycin Biosynthetic Gene Cluster fromInternational journal of molecular sciences · 2024Article
- Diversity and potential functional role of phyllosphere-associated actinomycetota isolated from cupuassu (Theobroma grandiflorum) leaves: implications for ecosystem dynamics and plant defense strategies.Molecular genetics and genomics : MGG · 2024Article
- Model-driven characterization of functional diversity ofMicrobial genomics · 2024Article
- Functional host-specific adaptation of the intestinal microbiome in hominids.Nature communications · 2024Article
- Insights into virulence: structure classification of themSystems · 2023Article
- Alkylresorcinols as New Modulators of the Metabolic Activity of the Gut Microbiota.International journal of molecular sciences · 2023Article
- Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition.Nature metabolism · 2023Article
- Rethinking Biosynthesis of Aclacinomycin A.Molecules (Basel, Switzerland) · 2023Review
- An updated catalogue of diverse type II polyketide synthase biosynthetic gene clusters captured from large-scale nucleotide databases.Microbial genomics · 2023Article
- Metabolic Network Models of themSystems · 2023Article
- Glacier-Fed Stream Biofilms Harbor Diverse Resistomes and Biosynthetic Gene Clusters.Microbiology spectrum · 2023Article
- Natural product drug discovery in the artificial intelligence era.Chemical science · 2022Review
- Structural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis.Scientific reports · 2021Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The emergence of resistant strains of human pathogens to current antibiotics, along with the demonstrated ability of polyketides as antimicrobial agents, provides strong motivation for understanding how polyketide antibiotics have evolved and diversified in nature. Insights into how bacterial polyketide synthases (PKSs) acquire new metabolic capabilities can guide future laboratory efforts in generating the next generation of polyketide antibiotics. Here, we examine phylogenetic and structural evidence to glean answers to two general questions regarding PKS evolution. How did the exceptionally diverse chemistry of present-day PKSs evolve? And what are the take-home messages for the biosynthetic engineer?
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.