ArticleThe Journal of cell biology2008
A microtubule-destabilizing kinesin motor regulates spindle length and anchoring in oocytes.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Mechanical states of a motor protein in the spindle.Current biology : CB · 2026Article
- NuSAP4 regulates chromosome segregation in Trypanosoma brucei by promoting bipolar spindle assembly.Communications biology · 2024Article
- The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing.Frontiers in cell and developmental biology · 2023Review
- Orbit/CLASP determines centriole length by antagonising Klp10A inJournal of cell science · 2021Article
- Female Meiosis: Synapsis, Recombination, and Segregation inGenetics · 2018Review
- Inhibition of ectopic microtubule assembly by the kinesin-13 KLP-7 prevents chromosome segregation and cytokinesis defects in oocytes.Development (Cambridge, England) · 2017Article
- KIF2A regulates the spindle assembly and the metaphase I-anaphase I transition in mouse oocyte.Scientific reports · 2016Article
- Techniques for Imaging Prometaphase and Metaphase of Meiosis I in Fixed Drosophila Oocytes.Journal of visualized experiments : JoVE · 2016Article
- Oocyte Meiotic Spindle Assembly and Function.Current topics in developmental biology · 2016Review
- KLP-7 acts through the Ndc80 complex to limit pole number in C. elegans oocyte meiotic spindle assembly.The Journal of cell biology · 2015Article
- The kinesin-13 KLP10A motor regulates oocyte spindle length and affects EB1 binding without altering microtubule growth rates.Biology open · 2014Article
- Microtubule-depolymerizing kinesin KLP10A restricts the length of the acentrosomal meiotic spindle in Drosophila females.Genetics · 2012Article
- Altered nucleotide-microtubule coupling and increased mechanical output by a kinesin mutant.PloS one · 2012Article
- Gamma-tubulin is required for bipolar spindle assembly and for proper kinetochore microtubule attachments during prometaphase I in Drosophila oocytes.PLoS genetics · 2011Article
- Kinesins at a glance.Journal of cell science · 2010Article
- Anastral spindle assembly: a mathematical model.Biophysical journal · 2009Article
- Ncd motor binding and transport in the spindle.Journal of cell science · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The kinesin-13 motor, KLP10A, destabilizes microtubules at their minus ends in mitosis and binds to polymerizing plus ends in interphase, regulating spindle and microtubule dynamics. Little is known about kinesin-13 motors in meiosis. In this study, we report that KLP10A localizes to the unusual pole bodies of anastral Drosophila melanogaster oocyte meiosis I spindles as well as spindle fibers, centromeres, and cortical microtubules. We frequently observe the pole bodies attached to cortical microtubules, indicating that KLP10A could mediate spindle anchoring to the cortex via cortical microtubules. Oocytes treated with drugs that suppress microtubule dynamics exhibit spindles that are reoriented more vertically to the cortex than untreated controls. A dominant-negative klp10A mutant shows both reoriented and shorter oocyte spindles, implying that, unexpectedly, KLP10A may stabilize rather than destabilize microtubules, regulating spindle length and positioning the oocyte spindle. By altering microtubule dynamics, KLP10A could promote spindle reorientation upon oocyte activation.
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