ArticleMolecular and cellular biology2008
Acinus-S' represses retinoic acid receptor (RAR)-regulated gene expression through interaction with the B domains of RARs.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- The splicing factor Acin1 is essential for embryonic development but has limited effects on muscle structure and homeostasis.Scientific reports · 2025Article
- Retinoic acids and nuclear receptor signaling in liver development: Pathogenic roles in liver diseases.Pediatric discovery · 2024Review
- Arabidopsis ACINUS is O-glycosylated and regulates transcription and alternative splicing of regulators of reproductive transitions.Nature communications · 2021Article
- Efficient Therapeutic Delivery by a Novel Cell-Penetrating Peptide Derived from Acinus.Cancers · 2020Article
- Article
- Multifaceted Regulation of Gene Expression by the Apoptosis- and Splicing-Associated Protein Complex and Its Components.International journal of biological sciences · 2017Review
- Role of the nucleus in apoptosis: signaling and execution.Cellular and molecular life sciences : CMLS · 2015Review
- Role of Acinus in regulating retinoic acid-responsive gene pre-mRNA splicing.Journal of cellular physiology · 2015Article
- The SAP motif and C-terminal RS- and RD/E-rich region influences the sub-nuclear localization of Acinus isoforms.Journal of cellular biochemistry · 2014Article
- The exon junction complex controls transposable element activity by ensuring faithful splicing of the piwi transcript.Genes & development · 2014Article
- Vitamin A and retinoid signaling: genomic and nongenomic effects.Journal of lipid research · 2013Review
- Role of COUP-TFI during retinoic acid-induced differentiation of P19 cells to endodermal cells.Journal of cellular physiology · 2013Article
- Role of SF-1 and DAX-1 during differentiation of P19 cells by retinoic acid.Journal of cellular physiology · 2012Article
- The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex.Nature structural & molecular biology · 2012Article
- Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials.Critical reviews in eukaryotic gene expression · 2011Review
- Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold.RNA (New York, N.Y.) · 2010Article
- NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association.Oncogene · 2009Article
- HACE1: A novel repressor of RAR transcriptional activity.Journal of cellular biochemistry · 2009Article
- Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).Nuclear receptor signaling · 2009Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The diverse biological actions of retinoic acid (RA) are mediated by RA receptors (RARs) and retinoid X receptors (RXRs). Modulation of transcription by RARs/RXRs is achieved through two activation functions, ligand-independent AF-1 and ligand-dependent AF-2, located in the A/B and E domains, respectively. While the coregulatory proteins that interact with the E domain are well studied, the A/B domain-interacting partners and their influence(s) on the function of RARs are poorly understood. Acinus-S' is an ubiquitous nuclear protein that has been implicated in inducing apoptotic chromatin condensation and regulating mRNA processing. Our data demonstrate that Acinus-S' can specifically repress ligand-independent and ligand-dependent expression of a DR5 RA response element(RARE)-dependent reporter gene and several endogenous RAR-regulated genes in a dose-dependent and gene-specific manner. Chromatin immunoprecipitation assays show that Acinus-S' associates with RAREs within the promoters of endogenous genes independent of RA treatment. Furthermore, the C-terminal end of Acinus-S' and the B domain of RARbeta interact independently of ligand, and the C-terminal end of Acinus-S' is sufficient for the repression of RAR-regulated gene expression. Finally, histone deacetylase activity only partially accounts for the repressive effect of Acinus-S' on RAR-dependent gene expression. These findings identify Acinus-S' as a novel RAR-interacting protein that regulates the expression of a subset of RAR-regulated genes through direct binding to the N-terminal B domains of RARs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.