ArticleCerebral cortex (New York, N.Y. : 1991)2008
V1 projection zone signals in human macular degeneration depend on task, not stimulus.
Article in Cerebral cortex (New York, N.Y. : 1991), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
86 citing papers in PubMed, 150 citations in OpenAlex.
- Biofeedback Rehabilitation and Visual Cortex Response in Stargardt's Disease: A Randomized Controlled Trial.Translational vision science & technology · 2020Trial
- Surface-Based Analyses of Anatomical Properties of the Visual Cortex in Macular Degeneration.PloS one · 2016Trial
- Cortical reorganization after long-term adaptation to retinal lesions in humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- The human visual cortex responds to gene therapy-mediated recovery of retinal function.The Journal of clinical investigation · 2011Trial
- Increased Attentive Use Is Linked to More Idiosyncratic Functional Connections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neurobehavioral Changes in Macular Degeneration: Spatial Frequency Use in Scene Recognition.Investigative ophthalmology & visual science · 2025Article
- Cortical response to transient and long-term visual field loss.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Motion Processing in Visual Cortex of Maculopathy Patients.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Use of functional magnetic resonance imaging in the evaluation of neural plasticity in macular degeneration.Frontiers in neuroscience · 2025Review
- Impact of Deprivation and Preferential Usage on Functional Connectivity Between Early Visual Cortex and Category-Selective Visual Regions.Human brain mapping · 2024Article
- Good vision without peripheries: behavioral and fMRI evidence.Scientific reports · 2024Article
- Assessment of objective visual function following idebenone administration in patients with leber hereditary optic neuropathy.Japanese journal of ophthalmology · 2024Article
- Learning Improves Peripheral Vision Via Enhanced Cortico-Cortical Communications.Neuroscience bulletin · 2024Article
- A selection and targeting framework of cortical locations for line-scanning fMRI.Human brain mapping · 2023Article
- Cortical plasticity in central vision loss: Cortical thickness and neurite structure.Human brain mapping · 2023Article
- Consistency of preferred retinal locus across tasks and participants trained with a simulated scotoma.Vision research · 2023Article
- Functional Connectivity Hypointensity of Middle Cingulate Gyrus and Thalamus in Age-Related Macular Degeneration Patients: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in aging neuroscience · 2022Article
- Laminar functional magnetic resonance imaging in vision research.Frontiers in neuroscience · 2022Review
- Macaque Area V2/V3 Reorganization Following Homonymous Retinal Lesions.Frontiers in neuroscience · 2022Article
- Benefits of Implementing Eye-Movement Training in the Rehabilitation of Patients with Age-Related Macular Degeneration: A Review.Brain sciences · 2021Review
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
We used functional magnetic resonance imaging to assess abnormal cortical signals in humans with juvenile macular degeneration (JMD). These signals have been interpreted as indicating large-scale cortical reorganization. Subjects viewed a stimulus passively or performed a task; the task was either related or unrelated to the stimulus. During passive viewing, or while performing tasks unrelated to the stimulus, there were large unresponsive V1 regions. These regions included the foveal projection zone, and we refer to them as the lesion projection zone (LPZ). In 3 JMD subjects, we observed highly significant responses in the LPZ while they performed stimulus-related judgments. In control subjects, where we presented the stimulus only within the peripheral visual field, there was no V1 response in the foveal projection zone in any condition. The difference between JMD and control responses can be explained by hypotheses that have very different implications for V1 reorganization. In controls retinal afferents carry signals indicating the presence of a uniform (zero-contrast) region of the visual field. Deletion of retinal input may 1) spur the formation of new cortical pathways that carry task-dependent signals (reorganization), or 2) unmask preexisting task-dependent cortical signals that ordinarily are suppressed by the deleted signals (no reorganization).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.