ArticleReproductive toxicology (Elmsford, N.Y.)2008
Circulating estradiol in men is inversely related to urinary metabolites of nonpersistent insecticides.
Article in Reproductive toxicology (Elmsford, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00011713 (Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.
Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Reference values of urinary metabolites of organophosphate in healthy Iranian adults.PloS one · 2025Article
- Sex and adrenal hormones in association with insecticide biomarkers among adolescents living in ecuadorian agricultural communities.International journal of hygiene and environmental health · 2024Article
- Endocrine-disrupting chemicals and male reproductive health.Fertility and sterility · 2023Review
- Probabilistic health risk assessment of chlorpyrifos exposure among applicators on rice farms in Ghana.Environmental science and pollution research international · 2021Article
- Health Effects of Naphthalene Exposure: A Systematic Evidence Map and Analysis of Potential Considerations for Dose-Response Evaluation.Environmental health perspectives · 2021Article
- Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand.International journal of environmental research and public health · 2021Article
- Endocrine Disrupting Chemicals and Reproductive Health in Boys and Men.Frontiers in endocrinology · 2021Review
- Pesticide exposure and risk of aggressive prostate cancer among private pesticide applicators.Environmental health : a global access science source · 2020Article
- Effects of Diethyl Phosphate, a Non-Specific Metabolite of Organophosphorus Pesticides, on Serum Lipid, Hormones, Inflammation, and Gut Microbiota.Molecules (Basel, Switzerland) · 2019Article
- Xenoestrogen interference with nongenomic signaling actions of physiological estrogens in endocrine cancer cells.Steroids · 2019Article
- Review
- Endocrine actions of pesticides measured in the Flemish environment and health studies (FLEHS I and II).Environmental science and pollution research international · 2015Article
- Association between urinary biomarkers of exposure to organophosphate insecticides and serum reproductive hormones in men from NHANES 1999-2002.Reproductive toxicology (Elmsford, N.Y.) · 2015Article
- Distribution and determinants of urinary biomarkers of exposure to organophosphate insecticides in Puerto Rican pregnant women.The Science of the total environment · 2015Article
- Effect of nonpersistent pesticides on estrogen receptor, androgen receptor, and aryl hydrocarbon receptor.Environmental toxicology · 2014Article
- The effect of Carbaryl on the pituitary-gonad axis in male rats.Iranian journal of reproductive medicine · 2012Article
- House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters.Environmental health perspectives · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEstradiol plays an important role in male reproductive health as a germ cell survival factor. Chlorpyrifos and carbaryl, nonpersistent insecticides to which the general population are commonly exposed, were recently shown to inhibit estradiol metabolism in vitro which could lead to altered hormone balance.
methodsSubjects (N=322) were the male partners in couples presenting to a Massachusetts infertility clinic from years 2000-2003. 3,5,6-Trichloro-2-pyridinol (TCPY), the major urinary metabolite of chlorpyrifos and chlorpyrifos-methyl, and 1- and 2-naphthol (1N and 2N), urinary metabolites of carbaryl and naphthalene, were measured in a spot urine sample from each subject. Estradiol, sex hormone binding globulin (SHBG), and prolactin were measured in serum collected from subjects during the same clinic visit.
resultsUsing multiple linear regression, an interquartile range (IQR) increase in TCPY was associated with a 1.36 pg/mL decline (95% confidence interval=-2.91 to -0.22) in estradiol concentration. When estradiol and TCPY were divided into quintiles, there was a dose-dependent increase in the odds of being in the lowest estradiol quintile with increasing TCPY quintiles.
conclusionOn a population level, these reductions in estradiol levels are of potential public health importance because of widespread exposure to TCPY and its parent insecticides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.