ArticleThe Journal of cell biology1991
Multiple pathways in nuclear transport: the import of U2 snRNP occurs by a novel kinetic pathway.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- RNA export through the nuclear pore complex: pathways, mechanisms, and imaging strategies.RNA biology · 2026Review
- Translocations involving anaplastic lymphoma kinase (ALK).Oncogene · 2001Review
- A novel nuclear import pathway for the transcription factor TFIIS.The Journal of cell biology · 1998Article
- Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure.The EMBO journal · 1998Article
- A nuclear import pathway for a protein involved in tRNA maturation.The Journal of cell biology · 1997Article
- Inhibition of mRNA export in vertebrate cells by nuclear export signal conjugates.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Nuclear import and export of influenza virus nucleoprotein.Journal of virology · 1997Article
- Nuclear import of U snRNPs requires importin beta.The EMBO journal · 1997Article
- A novel class of RanGTP binding proteins.The Journal of cell biology · 1997Article
- A role for HDJ-2/HSDJ in correcting subnuclear trafficking, transactivation, and transrepression defects of a glucocorticoid receptor zinc finger mutant.Molecular biology of the cell · 1997Article
- A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export.The Journal of cell biology · 1997Article
- The vertebrate GLFG nucleoporin, Nup98, is an essential component of multiple RNA export pathways.The Journal of cell biology · 1997Article
- In vivo nuclear transport kinetics in Saccharomyces cerevisiae: a role for heat shock protein 70 during targeting and translocation.The Journal of cell biology · 1996Article
- RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus.The Journal of cell biology · 1996Article
- Cytoplasmic retention and nuclear import of 5S ribosomal RNA containing RNPs.The EMBO journal · 1996Article
- Transport of DNA into the nuclei of xenopus oocytes by a modified VirE2 protein of Agrobacterium.The Plant cell · 1996Article
- Facilitated nuclear transport of calmodulin in tissue culture cells.The Journal of cell biology · 1994Article
- Nucleocytoplasmic transport.The Biochemical journal · 1994Review
- Nuclear transport of U1 snRNP in somatic cells: differences in signal requirement compared with Xenopus laevis oocytes.The Journal of cell biology · 1994Article
- Nuclear export of different classes of RNA is mediated by specific factors.The Journal of cell biology · 1994Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein import to the nucleus is a signal-mediated process that exhibits saturation kinetics. We investigated whether signal bearing proteins compete with U2 and U6 snRNPs during import. When injected into Xenopus oocytes, saturating concentrations of P(Lys)-BSA, a protein bearing multiple nuclear localization signals from SV40 large T-antigen, reduce the rate of [125I]P(Lys)-BSA and of [125I]nucleoplasmin import, consistent with their competing for and sharing the same limiting component of the import apparatus. In contrast, saturating concentrations of P(Lys)-BSA do not reduce the rate of HeLa [32P]U2 snRNP assembly or import. The import of U6 snRNP is also competed by P(Lys)-BSA. We conclude that U2 snRNP is imported into oocyte nuclei by a kinetic pathway that is distinct from the one followed by P(Lys)-BSA, nucleoplasmin, and U6 snRNP.
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