ArticleClinical and experimental immunology1991
Characterization of immune inducer and suppressor macrophages from the normal human lung.
Article in Clinical and experimental immunology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Characteristics of suppressor macrophages induced by mycobacterial and protozoal infections in relation to alternatively activated M2 macrophages.Clinical & developmental immunology · 2012Review
- Anti-allergic Activity of Stem Bark of Myrica esculenta Buch.-Ham. (Myricaceae).Journal of young pharmacists : JYP · 2010Article
- Complement components (C3, C4) in childhood asthma.Indian journal of pediatrics · 2005Article
- Thyroid associated ophthalmopathy: evidence for CD4(+) gammadelta T cells; de novo differentiation of RFD7(+) macrophages, but not of RFD1(+) dendritic cells; and loss of gammadelta and alphabeta T cell receptor expression.The British journal of ophthalmology · 2004Article
- Tumour necrosis factors in childhood asthma.Indian journal of pediatrics · 2001Article
- Fluticasone propionate-induced regulation of the balance within macrophage subpopulations.Clinical and experimental immunology · 2000Article
- Urban particle-induced apoptosis and phenotype shifts in human alveolar macrophages.Environmental health perspectives · 1998Article
- Asbestos and silica-induced changes in human alveolar macrophage phenotype.Environmental health perspectives · 1997Article
- T-cell cytokines may control the balance of functionally distinct macrophage populations.Immunology · 1997Article
- Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity.The American journal of pathology · 1997Article
- Immunohistochemical identification of type II alternatively activated dendritic macrophages (RM 3/1+3, MS-1+/-, 25F9-) in psoriatic dermis.Archives of dermatological research · 1996Article
- Cytokine modulation of the immunosuppressive phenotype of pulmonary alveolar macrophage populations.Immunology · 1995Article
- Article
- Presence of CD3+CD8+Bcl-2(low) lymphocytes undergoing apoptosis and activated macrophages in lymph nodes of HIV-1+ patients.The American journal of pathology · 1995Article
- Enrichment and characterization of dendritic cells from human bronchoalveolar lavages.Clinical and experimental immunology · 1994Article
- Suppression of murine IgM, IgG, IgA and IgE antibody responses by alveolar macrophages.Immunology · 1993Article
- Mucosal macrophage subsets of the gut in HIV: decrease in antigen-presenting cell phenotype.Clinical and experimental immunology · 1993Article
- Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor.The Journal of experimental medicine · 1993Article
- Inducible expression of MS-1 high-molecular-weight protein by endothelial cells of continuous origin and by dendritic cells/macrophages in vivo and in vitro.The American journal of pathology · 1993Article
- Synovial fluid antigen-presenting cell function in rheumatoid arthritis.Clinical and experimental immunology · 1993Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monoclonal antibodies (MoAbs) that are able to discriminate between dendritic cells (MoAb RFD1+) and mature macrophages (MoAb RFD7+) in normal tissues were used in combination with density separation techniques to isolate relatively homogeneous subpopulations of macrophages from human bronchoalveolar lavage (BAL). A characterization of surface antigen expression, and functional capacity was then carried out on each isolated alveolar macrophage (AM) subset. One population with the phenotype RFD1+RFD7- obtained from the non-adherent cell pool showed the characteristics of antigen-presenting cells having absent or poor expression of Fc and C3b receptors, a low content of lysozomal hydrolase and poor phagocytic capacity. This population strongly stimulated T lymphocytes in allogeneic mixed lymphocyte reactions (MLR). A second AM population, isolated by adherence and density centrifugation expressed the phenotype RFD1+RFD7+. These cells showed the same phenotypic characteristics of mature macrophages with strong expression of C3b and Fc receptors, and marked phagocytic capacity. Such AM were very poor stimulators of allogeneic MLR. Under certain circumstances the RFD1+RFD7+ cells were shown to actively repress the stimulatory capacity of the RFD1+RFD7- subpopulation. These results suggest that variations within the functional capacity of AM subsets may be capable of influencing the strength of acquired T cell immune responses of the lung.
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