Trial reportJournal of general internal medicine2008
Primary versus specialty care outcomes for depressed outpatients managed with measurement-based care: results from STAR*D.
Trial report in Journal of general internal medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 99 citations in OpenAlex.
- Trial
- When "need plus supply" does not equal demand: challenges in uptake of depression treatment in HIV clinical care.Psychiatric services (Washington, D.C.) · 2015Trial
- A double-blind, randomized controlled clinical trial comparing eicosapentaenoic acid versus docosahexaenoic acid for depression.The Journal of clinical psychiatry · 2015Trial
- Trial
- Assessing the effect of Measurement-Based Care depression treatment on HIV medication adherence and health outcomes: rationale and design of the SLAM DUNC Study.Contemporary clinical trials · 2012Trial
- Wishing upon a STAR*D: the promise of ideal depression care by primary care providers.Psychiatric services (Washington, D.C.) · 2009Trial
- Whose Truth Is Ground Truth?: Consequences of Label Choice on Machine Learning Models Predicting Depression.Research square · 2026Article
- New and emerging pharmacologic treatments for MDD.Frontiers in psychiatry · 2025Review
- Frontal Pole Neuromodulation for Impulsivity and Suicidality in Veterans With Mild Traumatic Brain Injury and Common Co-Occurring Mental Health Conditions: Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2024Article
- Care pathways, prescribing practices and treatment outcomes in major depressive disorder and treatment-resistant depression: retrospective, population-based cohort study.BJPsych open · 2024Article
- Stigma towards opioid use disorder in primary care remain a barrier to integrating software-based measurement based care.BMC psychiatry · 2023Article
- Standardized Versus Tailored Implementation of Measurement-Based Care for Depression in Community Mental Health Clinics.Psychiatric services (Washington, D.C.) · 2022Article
- The Patient Mania Questionnaire (PMQ-9): a Brief Scale for Assessing and Monitoring Manic Symptoms.Journal of general internal medicine · 2022Article
- Reliability and Validity of the Urdu Version of Psychosomatic Symptoms Scale in Pakistani Patients.Frontiers in psychology · 2022Article
- The Sub-Saharan Africa Regional Partnership (SHARP) for Mental Health Capacity-Building Scale-Up Trial: Study Design and Protocol.Psychiatric services (Washington, D.C.) · 2021Article
- Creation of an algorithm for clinical decision support for treatment of opioid use disorder with buprenorphine in primary care.Addiction science & clinical practice · 2021Observational
- Minimally important differences and severity thresholds are estimated for the PROMIS depression scales from three randomized clinical trials.Journal of affective disorders · 2020Article
- The Role of Screening in Depression Diagnosis and Treatment in a Representative Sample of US Primary Care Visits.Journal of general internal medicine · 2020Article
- The effectiveness of depression management for improving HIV care outcomes in Malawi: protocol for a quasi-experimental study.BMC public health · 2019Article
- Screening and Management of Depression in Patients With Cardiovascular Disease: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundWhether the acute outcomes of major depressive disorder (MDD) treated in primary (PC) or specialty care (SC) settings are different is unknown.
objectiveTo compare the treatment and outcomes for depressed outpatients treated in primary versus specialty settings with citalopram in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study (www.star-d.org), a broadly inclusive effectiveness trial.
designOpen clinical trial with citalopram for up to 14 weeks at 18 primary and 23 specialty sites. Participants received measurement-based care with 5 recommended treatment visits, manualized pharmacotherapy, ongoing support and guidance by a clinical research coordinator, the use of structured evaluation of depressive symptoms and side effects at each visit, and a centralized treatment monitoring and feedback system.
participantsA total of 2,876 previously established outpatients in primary (n = 1091) or specialty (n = 1785) with nonpsychotic depression who had at least 1 post-baseline measure. MEASUREMENTS AND MAIN
resultsRemission (Hamilton Depression Rating Scale for Depression [Hamilton] or 16-item Quick Inventory of Depressive Symptomatology-Self-Rated [QIDS-SR(16)]); response (QIDS-SR(16)); time to first remission (QIDS-SR(16)). Remission rates by Hamilton (26.6% PC vs 28.0% SC, p = .40) and by QIDS-SR(16) (32.5% PC vs 33.1% SC, p = .78) and response rates by QIDS-SR(16) (45.7% PC vs 47.6% SC, p = .33) were not different. For those who reached remission or response at exit, the time to remission (6.2 weeks PC vs 6.9 weeks SC, p = .12) and to response (5.5 weeks PC vs 5.4 weeks SC, p = .97) did not differ by setting.
conclusionsIdentical remission and response rates can be achieved in primary and specialty settings when identical care is provided.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.