Evidence map›Paper›PMID 18247059›Full record

ReviewHuman genetics2008

Leprosy as a genetic model for susceptibility to common infectious diseases.

Andrea Alter, Alexandre Alcaïs, Laurent Abel, Erwin Schurr

Abstract readReview
PubMed Publisher
In one paragraph

Review in Human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Impact ofBioscience reports · 2017
    Pooled it
  2. Pooled it
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  5. Review
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  15. Review
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  18. Leprosy: an overview of pathophysiology.Interdisciplinary perspectives on infectious diseases · 2012
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Andrea AlterMcGill Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, 1650 Cedar Avenue, Montreal, H3G 1A4, QC, Canada.
Alexandre Alcaïs
Laurent Abel
Erwin Schurr
McGill University Health Centre · CAHuman Genetic of Infectious Diseases · FRUniversité Paris Cité · FR

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Leprosy (Hansen's disease) is a human infectious disease that can be effectively treated with long-term administration of multi-drug therapy. In 2006, over 250,000 new cases were reported to the World Health Organization. In the nineteenth century, disagreement among leprologists regarding the hereditary or infectious nature of leprosy was resolved with the identification of the etiological agent, Mycobacterium leprae. However, epidemiological studies maintain the importance of host genetics in leprosy susceptibility. A model free genome-wide linkage scan in multi-case families from Vietnam led to the positional cloning of global genetic risk factors in the PARK2/PACRG and LTA genes. The process of identifying the susceptibility variants provided invaluable insight into the replication of genetic effects, particularly the importance of considering population-specific linkage-disequilibrium structure. As such, these studies serve to improve our understanding of leprosy pathogenesis by implicating novel biological pathways while simultaneously providing a genetic model for common infectious diseases.

Indexed as

Genetic Predisposition to DiseaseModels, GeneticHumansLeprosyMicrofilament ProteinsMolecular ChaperonesMycobacterium lepraeUbiquitin-Protein LigasesMicrofilament ProteinsMolecular ChaperonesPACRG protein, humanparkin proteinUbiquitin-Protein Ligases

Identifiers

PMID18247059
OpenAlexW2003914797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.