ArticleEuropean biophysics journal : EBJ2008
Stimulation of human olfactory receptor 17-40 with odorants probed by surface plasmon resonance.
Article in European biophysics journal : EBJ, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 27 citations in OpenAlex.
- Exploring Scent Distinction with Polymer Brush Arrays.ACS applied polymer materials · 2025Article
- An Overview of Artificial Olfaction Systems with a Focus on Surface Plasmon Resonance for the Analysis of Volatile Organic Compounds.Biosensors · 2021Review
- Responses of the Pheromone-Binding Protein of the Silk MothSensors (Basel, Switzerland) · 2021Article
- Immobilization of Olfactory Receptors Carried by Nanosomes onto a Gold Sensor Surface.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Bioelectronic nose and its application to smell visualization.Journal of biological engineering · 2016Review
- Surface plasmon resonance applied to G protein-coupled receptors.Biomedical spectroscopy and imaging · 2013Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report here the results of human olfactory receptor (OR) 17-40 stimulation with some odorants probed by means of the double-channel surface plasmon resonance platform NanoSPR-6. OR 17-40 tagged with N-terminal cmyc sequence was heterologously co-expressed with Galpha(olf) protein in yeast, and receptor-carrying nanosomes were prepared from yeast membrane fraction. Then, receptors were specifically captured via anti-cmyc antibody attached to the gold-coated substrate in orientated or random way. Measurement of odorants effects were carried out in the presence of GTP-gamma-S in differential mode in order to compensate bulk changes of refractive index. For the first time, biosensing efficiency of olfactory films was discussed in terms of their thickness and Galpha(olf) accessibility to GTP-gamma-S. Bell-shaped response profile with two maxima (near 1 nM and near 1 microM) was established for helional, which is documented as highly specific agonist of OR 17-40. Unrelated odorant heptanal used as control, did not evoke significant variations of differential signal.
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Registered trials
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