ArticleGenetics2008
Adaptive functional divergence among triplicated alpha-globin genes in rodents.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
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- The adaptive benefit of evolved increases in hemoglobin-OBMC biology · 2021Article
- An Insect Counteradaptation against Host Plant Defenses Evolved through Concerted Neofunctionalization.Molecular biology and evolution · 2019Article
- Genome-Wide Microarray Analysis Suggests Transcriptomic Response May Not Play a Major Role in High- to Low-Altitude Acclimation in Harvest Mouse (Animals : an open access journal from MDPI · 2019Article
- Gene Turnover and Diversification of the α- and β-Globin Gene Families in Sauropsid Vertebrates.Genome biology and evolution · 2018Article
- Intraspecific polymorphism, interspecific divergence, and the origins of function-altering mutations in deer mouse hemoglobin.Molecular biology and evolution · 2015Article
- Gene turnover in the avian globin gene families and evolutionary changes in hemoglobin isoform expression.Molecular biology and evolution · 2015Article
- Phylogenetic Patterns of Codon Evolution in the ACTIN-DEPOLYMERIZING FACTOR/COFILIN (ADF/CFL) Gene Family.PloS one · 2015Article
- Article
- Repeated evolution of chimeric fusion genes in the β-globin gene family of laurasiatherian mammals.Genome biology and evolution · 2014Article
- Genomic organization and differential signature of positive selection in the alpha and beta globin gene clusters in two cetacean species.Genome biology and evolution · 2013Article
- Genomic characterization of the European sea bass Dicentrarchus labrax reveals the presence of a novel uncoupling protein (UCP) gene family member in the teleost fish lineage.BMC evolutionary biology · 2012Article
- Copy number polymorphism in the α-globin gene cluster of European rabbit (Oryctolagus cuniculus).Heredity · 2012Article
- Altitudinal variation at duplicated β-globin genes in deer mice: effects of selection, recombination, and gene conversion.Genetics · 2012Article
- Dynamic programming procedure for searching optimal models to estimate substitution rates based on the maximum-likelihood method.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Review
- Developmental regulation of hemoglobin synthesis in the green anole lizard Anolis carolinensis.The Journal of experimental biology · 2011Article
- Genetic differences in hemoglobin function between highland and lowland deer mice.The Journal of experimental biology · 2010Article
- Lineage-specific patterns of functional diversification in the alpha- and beta-globin gene families of tetrapod vertebrates.Molecular biology and evolution · 2010Article
- Evolution of duplicated beta-globin genes and the structural basis of hemoglobin isoform differentiation in Mus.Molecular biology and evolution · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The functional divergence of duplicated genes is thought to play an important role in the evolution of new developmental and physiological pathways, but the role of positive selection in driving this process remains controversial. The objective of this study was to test whether amino acid differences among triplicated alpha-globin paralogs of the Norway rat (Rattus norvegicus) and the deer mouse (Peromyscus maniculatus) are attributable to a relaxation of purifying selection or to a history of positive selection that has adapted the gene products to new or modified physiological tasks. In each rodent species, the two paralogs at the 5'-end of the alpha-globin gene cluster (HBA-T1 and HBA-T2) are evolving in concert and are therefore identical or nearly identical in sequence. However, in each case, the HBA-T1 and HBA-T2 paralogs are distinguished from the third paralog at the 3'-end of the gene cluster (HBA-T3) by multiple amino acid substitutions. An analysis of genomic sequence data from several rodent species revealed that the HBA-T3 genes of Rattus and Peromyscus originated via independent, lineage-specific duplication events. In the independently derived HBA-T3 genes of both species, a likelihood analysis based on a codon-substitution model revealed that accelerated rates of amino acid substitution are attributable to positive directional selection, not to a relaxation of purifying selection. As a result of functional divergence among the triplicated alpha-globin genes in Rattus and Peromyscus, the red blood cells of both rodent species contain a mixture of functionally distinct alpha-chain hemoglobin isoforms that are predicted to have different oxygen-binding affinities. In P. maniculatus, a species that is able to sustain physiological function under conditions of chronic hypoxia at high altitude, the coexpression of distinct hemoglobin isoforms with graded oxygen affinities is expected to broaden the permissible range of arterial oxygen tensions for pulmonary/tissue oxygen transport.
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